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Literature DB >> 1103723

Stability of amphotericin B in fungal culture media.

S C Cheung, G Medoff, D Schlessinger, G S Kobayashi.

Abstract

We have found that amphotericin B is unstable in two commonly employed fungal culture media. This instability leads to inaccuracies in determining the actual level of susceptibility of slow-growing strains that require prolonged incubation for growth. To help compensate for this problem, we have described two rapid methods of susceptibility testing.

Entities: Chemical

Mesh：

Substances：

Year: 1975 PMID： 1103723 PMCID： PMC429362 DOI： 10.1128/AAC.8.4.426

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

10 in total

1. Amphotericin B and other polyene antifungal antibiotics: photometric assay and factors influencing activity.

Authors: J R GERKE; M E MADIGAN
Journal: Antibiot Chemother (Northfield) Date: 1961-04

2. Growth of the yeastlike phase of Histoplasma capsulatum in a fluid medium.

Authors: S B SALVIN
Journal: J Bacteriol Date: 1950-02 Impact factor: 3.490

3. Inactivation of amphotericin B by reducing agents: influences on growth inhibition of Candida albicans and lysis of erythrocytes.

Authors: M R Weis; H B Levine
Journal: Sabouraudia Date: 1972-07

4. Stability of amphotericin B in infusion bottles.

Authors: E R Block; J E Bennett
Journal: Antimicrob Agents Chemother Date: 1973-12 Impact factor: 5.191

5. Light sensitivity of prepared solutions of amphotericin B.

Authors: S Shadomy; D L Brummer; A V Ingroff
Journal: Am Rev Respir Dis Date: 1973-02

6. The effect of pH and of temperature on the stability and bioactivity of nystatin and amphotericin B.

Authors: J M Hamilton-Miller
Journal: J Pharm Pharmacol Date: 1973-05 Impact factor: 3.765

7. Rapid radiometric method of testing susceptibility of mycobacteria and slow-growing fungi to antimicrobial agents.

Authors: P Benitez; G Medoff; G S Kobayashi
Journal: Antimicrob Agents Chemother Date: 1974-07 Impact factor: 5.191

8. In vitro susceptibility of isolates of Aspergillus fumigatus and Sporothrix schenckii to amphotericin B.

Authors: J W Brandsberg; M E French
Journal: Antimicrob Agents Chemother Date: 1972-11 Impact factor: 5.191

9. Bioassay for hamycin and amphotericin B in serum and other biological fluids.

Authors: S Shadomy; J A McCay; S I Schwartz
Journal: Appl Microbiol Date: 1969-04

10. Amphotericin B serum concentrations during therapy.

Authors: B T Fields; J H Bates; R S Abernathy
Journal: Appl Microbiol Date: 1970-06

10 in total

11 in total

Stability of amphotericin B in fungal culture media.

1. Amphotericin B and other polyene antifungal antibiotics: photometric assay and factors influencing activity.

2. Growth of the yeastlike phase of Histoplasma capsulatum in a fluid medium.

3. Inactivation of amphotericin B by reducing agents: influences on growth inhibition of Candida albicans and lysis of erythrocytes.

4. Stability of amphotericin B in infusion bottles.

5. Light sensitivity of prepared solutions of amphotericin B.

6. The effect of pH and of temperature on the stability and bioactivity of nystatin and amphotericin B.

7. Rapid radiometric method of testing susceptibility of mycobacteria and slow-growing fungi to antimicrobial agents.

8. In vitro susceptibility of isolates of Aspergillus fumigatus and Sporothrix schenckii to amphotericin B.

9. Bioassay for hamycin and amphotericin B in serum and other biological fluids.

10. Amphotericin B serum concentrations during therapy.

1. Effect of amphotericin B on growth and membrane permeability in Dictyostelium discoideum.

2. Influence of antioxidants on the bioactivity of amphotericin B.

3. Antimicrobial susceptibility testing of six clinical isolates of Aspergillus.

Review 4. Antifungal drug susceptibility testing. A critical review.

5. Discrepant results of amphotericin B assays on fresh versus frozen serum samples.

6. Determination of the minimal inhibitory concentration of amphotericin B and miconazole for 21 strains of Aspergillus.

7. Detection of contamination during organ culture of the human cornea.

8. The effects of amphotericin B on lipid metabolism in cultured human skin fibroblasts.

9. Discrepancies between MIC and MLC values of amphotericin B against isolates of Aspergillus species.

10. Combined activity of minocycline and amphotericin B in vitro against medically important yeasts.