Literature DB >> 4086422

The effects of amphotericin B on lipid metabolism in cultured human skin fibroblasts.

R A Levy, R E Ostlund, J Brajtburg.   

Abstract

Amphotericin B inhibits hydroxymethylglutarylcoenzyme A (HMGCoA) reductase activity and incorporation of [3H]acetate into sterols and fatty acids of human skin fibroblasts. Delivery of cholesterol to cells via the low density lipoprotein receptor pathway is not altered. The effects of amphotericin B on cell lipid metabolism are partially reversed by both potassium and insulin.

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Year:  1985        PMID： 4086422     DOI： 10.1007/BF02620910

Source DB:  PubMed          Journal:  In Vitro Cell Dev Biol        ISSN： 0883-8364


  22 in total

1.  A simple method for the isolation and purification of total lipides from animal tissues.

Authors:  J FOLCH; M LEES; G H SLOANE STANLEY
Journal:  J Biol Chem       Date:  1957-05       Impact factor: 5.157

2.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

3.  Role of microtubules in low density lipoprotein processing by cultured cells.

Authors:  R E Ostlund; B Pfleger; G Schonfeld
Journal:  J Clin Invest       Date:  1979-01       Impact factor: 14.808

4.  Side effects of amphotericin B-deoxycholate (fungizone) and nystatin in chick cells in culture.

Authors:  D Dolberg; M J Bissell
Journal:  In Vitro       Date:  1974 Jul-Aug

Review 5.  Polyene antibiotic - sterol interaction.

Authors:  A W Norman; A M Spielvogel; R G Wong
Journal:  Adv Lipid Res       Date:  1976

6.  Human serum low density lipoprotein-sodium deoxycholate interaction.

Authors:  J Q Oeswein; P W Chun
Journal:  J Biol Chem       Date:  1983-03-25       Impact factor: 5.157

7.  Analysis of lipids and endothelial and smooth muscle cells of umbilical cord in familial homozygous hypercholesterolemia.

Authors:  R E Ostlund; S V Hajek; R A Levy; J L Witztum
Journal:  Metabolism       Date:  1981-03       Impact factor: 8.694

8.  Control of sterol synthesis and of hydroxymethylglutaryl CoA reductase in skin fibroblasts grown from patients with homozygous type II hyperlipoproteinemia.

Authors:  J Avigan; S J Bhathena; M E Schreiner
Journal:  J Lipid Res       Date:  1975-03       Impact factor: 5.922

9.  Molecular basis for the selective toxicity of amphotericin B for yeast and filipin for animal cells.

Authors:  J Kotler-Brajtburg; H D Price; G Medoff; D Schlessinger; G S Kobayashi
Journal:  Antimicrob Agents Chemother       Date:  1974-04       Impact factor: 5.191

10.  Inhibition of proliferation of a murine myeloma cell line and mitogen-stimulated B lymphocytes by the antibiotic amphotericin B (Fungizone).

Authors:  E V Walls; J E Kay
Journal:  Immunology       Date:  1982-09       Impact factor: 7.397
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  4 in total

Review 1.  Carrier effects on biological activity of amphotericin B.

Authors:  J Brajtburg; J Bolard
Journal:  Clin Microbiol Rev       Date:  1996-10       Impact factor: 26.132

2.  Amphotericin B incorporated into egg lecithin-bile salt mixed micelles: molecular and cellular aspects relevant to therapeutic efficacy in experimental mycoses.

Authors:  J Brajtburg; S Elberg; G S Kobayashi; J Bolard
Journal:  Antimicrob Agents Chemother       Date:  1994-02       Impact factor: 5.191

3.  The endocytic process in CHO cells, a toxic pathway of the polyene antibiotic amphotericin B.

Authors:  A Vertut-Doï; S I Ohnishi; J Bolard
Journal:  Antimicrob Agents Chemother       Date:  1994-10       Impact factor: 5.191

4.  Influence of diet on experimental toxicity of amphotericin B deoxycholate.

Authors:  P Chavanet; V Joly; D Rigaud; J Bolard; C Carbon; P Yeni
Journal:  Antimicrob Agents Chemother       Date:  1994-05       Impact factor: 5.191
  4 in total

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