| Literature DB >> 11036263 |
Y Mori1, K Imaizumi, T Katayama, T Yoneda, M Tohyama.
Abstract
Dendritic localization of the alpha subunit of Ca2+/calmodulin-dependent protein kinase II (alphaCaMKII) mRNA in CNS neurons requires its 3' untranslated region (3'UTR). We investigated this targeting mechanism by identifying two cis-acting elements in the 3'UTR. One is a 30-nucleotide element that mediated dendritic translocation. A homologous sequence in the 3'UTR of neurogranin, transcripts of which also reside in dendrites, also funtioned in cis to promote its dendritic transport. Other putative elements in the alphaCaMKII mRNA inhibit its transport in a resting state. This inhibition was removed in depolarized neurons, and such activity-dependent derepression was a primary requirement for their dendritic targeting.Entities:
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Year: 2000 PMID： 11036263 DOI： 10.1038/80591
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884