Literature DB >> 11036039

PMS-601, a new platelet-activating factor receptor antagonist that inhibits human immunodeficiency virus replication and potentiates zidovudine activity in macrophages.

M Martin1, N Serradji, N Dereuddre-Bosquet, G Le Pavec, G Fichet, A Lamouri, F Heymans, J J Godfroid, P Clayette, D Dormont.   

Abstract

We assessed the anti-human immunodeficiency virus (anti-HIV) activity in vitro of new platelet-activating factor (PAF) receptor antagonists, as PAF and viral replication are thought to be involved in HIV neuropathogenesis. We found that PMS-601 inhibited proinflammatory cytokine synthesis and HIV replication in macrophages and potentiated the antiretroviral activity of zidovudine. These results suggest that PMS-601 is of potential value as an adjuvant treatment for HIV infection.

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Year:  2000        PMID： 11036039      PMCID： PMC101619          DOI： 10.1128/AAC.44.11.3150-3154.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  32 in total

1.  Changes to AIDS dementia complex in the era of highly active antiretroviral therapy.

Authors:  G J Dore; P K Correll; Y Li; J M Kaldor; D A Cooper; B J Brew
Journal:  AIDS       Date:  1999-07-09       Impact factor: 4.177

2.  Suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency virus-associated dementia.

Authors:  H E Gendelman; J Zheng; C L Coulter; A Ghorpade; M Che; M Thylin; R Rubocki; Y Persidsky; F Hahn; J Reinhard; S Swindells
Journal:  J Infect Dis       Date:  1998-10       Impact factor: 5.226

3.  Possible participation of intracellular platelet-activating factor in tumor necrosis factor-alpha production by rat peritoneal macrophages.

Authors:  M Yamada; A Tanimoto; G Ichinowatari; H Yaginuma; K Ohuchi
Journal:  Eur J Pharmacol       Date:  1999-06-25       Impact factor: 4.432

4.  Randomized trial of the platelet-activating factor antagonist lexipafant in HIV-associated cognitive impairment. Neurological AIDS Research Consortium.

Authors:  G Schifitto; N Sacktor; K Marder; M P McDermott; J C McArthur; K Kieburtz; S Small; L G Epstein
Journal:  Neurology       Date:  1999-07-22       Impact factor: 9.910

5.  Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis.

Authors:  Y Persidsky; A Ghorpade; J Rasmussen; J Limoges; X J Liu; M Stins; M Fiala; D Way; K S Kim; M H Witte; M Weinand; L Carhart; H E Gendelman
Journal:  Am J Pathol       Date:  1999-11       Impact factor: 4.307

6.  Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.

Authors:  F J Palella; K M Delaney; A C Moorman; M O Loveless; J Fuhrer; G A Satten; D J Aschman; S D Holmberg
Journal:  N Engl J Med       Date:  1998-03-26       Impact factor: 91.245

7.  Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia.

Authors:  K Conant; A Garzino-Demo; A Nath; J C McArthur; W Halliday; C Power; R C Gallo; E O Major
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-17       Impact factor: 11.205

8.  Involvement of nuclear factor-kappa B in platelet-activating factor-mediated tumor necrosis factor-alpha expression.

Authors:  S Y Im; S J Han; H M Ko; J H Choi; S B Chun; D G Lee; T Y Ha; H K Lee
Journal:  Eur J Immunol       Date:  1997-11       Impact factor: 5.532

9.  Beta-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia.

Authors:  W Kelder; J C McArthur; T Nance-Sproson; D McClernon; D E Griffin
Journal:  Ann Neurol       Date:  1998-11       Impact factor: 10.422

10.  Chemokines and receptors in HIV encephalitis.

Authors:  V J Sanders; C A Pittman; M G White; G Wang; C A Wiley; C L Achim
Journal:  AIDS       Date:  1998-06-18       Impact factor: 4.177
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  6 in total

1.  Changes in soluble factor-mediated CD8+ cell-derived antiviral activity in cynomolgus macaques infected with simian immunodeficiency virus SIVmac251: relationship to biological markers of progression.

Authors:  Vincent Dioszeghy; Kadija Benlhassan-Chahour; Benoit Delache; Nathalie Dereuddre-Bosquet; Celine Aubenque; Gabriel Gras; Roger Le Grand; Bruno Vaslin
Journal:  J Virol       Date:  2006-01       Impact factor: 5.103

Review 2.  The Role of Platelet-Activating Factor in Chronic Inflammation, Immune Activation, and Comorbidities Associated with HIV Infection.

Authors:  Theodoros Kelesidis; Vasiliki Papakonstantinou; Paraskevi Detopoulou; Elizabeth Fragopoulou; Maria Chini; Marios C Lazanas; Smaragdi Antonopoulou
Journal:  AIDS Rev       Date:  2015 Oct-Dec       Impact factor: 2.500

Review 3.  CNS inflammation and macrophage/microglial biology associated with HIV-1 infection.

Authors:  Anjana Yadav; Ronald G Collman
Journal:  J Neuroimmune Pharmacol       Date:  2009-09-19       Impact factor: 4.147

4.  Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders.

Authors:  Dawn Eggert; Prasanta K Dash; Nawal Serradji; Chang-Zhi Dong; Pascal Clayette; Francoise Heymans; Huanyu Dou; Santhi Gorantla; Harris A Gelbard; Larisa Poluektova; Howard E Gendelman
Journal:  J Neuroimmunol       Date:  2009-06-21       Impact factor: 3.478

5.  PMS1077 sensitizes TNF-α induced apoptosis in human prostate cancer cells by blocking NF-κB signaling pathway.

Authors:  Jie Shi; Jing Chen; Nawal Serradji; Ximing Xu; Heng Zhou; Yinxing Ma; Zhihong Sun; Peng Jiang; Yuping Du; Jinbo Yang; Changzhi Dong; Qin Wang
Journal:  PLoS One       Date:  2013-04-09       Impact factor: 3.240

6.  In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients.

Authors:  Vasiliki D Papakonstantinou; Maria Chini; Nikos Mangafas; George M Stamatakis; Nickolaos Tsogas; Alexandros B Tsoupras; Katherina Psarra; Elizabeth Fragopoulou; Smaragdi Antonopoulou; Panagiotis Gargalianos; Constantinos A Demopoulos; Marios-C Lazanas
Journal:  Lipids Health Dis       Date:  2014-05-29       Impact factor: 3.876
  6 in total

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