BACKGROUND: Reduced, left-lateralized P3 amplitude has been reported in several studies focusing on electrophysiologic function in schizophrenia. Also, several lines of evidence suggest a similarity between schizophrenia and schizotypal personality disorder (SPD). This study was undertaken to determine the replicability of our previous finding of a left-lateralized P3 amplitude deficit in SPD. METHODS: We recorded event-related potentials in 21 SPD and 18 normal control subjects in an auditory "oddball" P3 paradigm. RESULTS: In the SPD subjects, but not in the control subjects, there was lower P3 amplitude at T3 compared with T4. CONCLUSIONS: These results are similar to the ones in our previous work and further support the presence of a left-lateralized P3 deficit in SPD.
BACKGROUND: Reduced, left-lateralized P3 amplitude has been reported in several studies focusing on electrophysiologic function in schizophrenia. Also, several lines of evidence suggest a similarity between schizophrenia and schizotypal personality disorder (SPD). This study was undertaken to determine the replicability of our previous finding of a left-lateralized P3 amplitude deficit in SPD. METHODS: We recorded event-related potentials in 21 SPD and 18 normal control subjects in an auditory "oddball" P3 paradigm. RESULTS: In the SPD subjects, but not in the control subjects, there was lower P3 amplitude at T3 compared with T4. CONCLUSIONS: These results are similar to the ones in our previous work and further support the presence of a left-lateralized P3 deficit in SPD.
Authors: Olga Rass; Jennifer K Forsyth; Giri P Krishnan; William P Hetrick; Mallory J Klaunig; Alan Breier; Brian F O'Donnell; Colleen A Brenner Journal: Schizophr Res Date: 2012-01-28 Impact factor: 4.939
Authors: Chandlee C Dickey; Istvan A Morocz; Daniel Minney; Margaret A Niznikiewicz; Martina M Voglmaier; Lawrence P Panych; Usman Khan; Rayna Zacks; Douglas P Terry; Martha E Shenton; Robert W McCarley Journal: Schizophr Res Date: 2010-04-01 Impact factor: 4.939
Authors: Yong-Wook Shin; Giri Krishnan; William P Hetrick; Colleen A Brenner; Anantha Shekhar; Frederick W Malloy; Brian F O'Donnell Journal: Schizophr Res Date: 2010-12 Impact factor: 4.939
Authors: Daniel C Javitt; Kevin M Spencer; Gunvant K Thaker; Georg Winterer; Mihály Hajós Journal: Nat Rev Drug Discov Date: 2008-01 Impact factor: 84.694
Authors: Margaret A Niznikiewicz; Kevin M Spencer; Chandlee Dickey; Martina Voglmaier; Larry J Seidman; Martha E Shenton; Robert W McCarley Journal: Schizophr Res Date: 2009-03-27 Impact factor: 4.939
Authors: Chandlee C Dickey; Istvan A Morocz; Margaret A Niznikiewicz; Martina Voglmaier; Sarah Toner; Usman Khan; Mark Dreusicke; Seung-Schik Yoo; Martha E Shenton; Robert W McCarley Journal: Schizophr Res Date: 2008-06-13 Impact factor: 4.939