Literature DB >> 11031286

Large-scale shape changes in proteins and macromolecular complexes.

M E Wall1, S C Gallagher, J Trewhella.   

Abstract

Proteins and RNA undergo intricate motions as they carry out functions in biological systems. These motions frequently entail large-scale conformational changes that induce changes in the surface structure, or shape, of a molecule. This review describes the experimental characterization of large-scale shape changes in proteins and macromolecular complexes and the effects of such changes on macromolecular behavior. We describe several important results that have been obtained by using small-angle scattering, which is emerging as a powerful technique for determining macromolecular shapes and elucidating the quaternary structure of macromolecular assemblies.

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Year:  2000        PMID： 11031286     DOI： 10.1146/annurev.physchem.51.1.355

Source DB:  PubMed          Journal:  Annu Rev Phys Chem        ISSN： 0066-426X            Impact factor:   12.703


  15 in total

1.  Mechanisms associated with cGMP binding and activation of cGMP-dependent protein kinase.

Authors:  Michael E Wall; Sharron H Francis; Jackie D Corbin; Kennard Grimes; Robyn Richie-Jannetta; Jun Kotera; Brian A Macdonald; Rowena R Gibson; Jill Trewhella
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-18       Impact factor: 11.205

2.  Determination of the topological shape of integral membrane protein light-harvesting complex LH2 from photosynthetic bacteria in the detergent solution by small-angle X-ray scattering.

Authors:  Xinguo Hong; Yu-Xiang Weng; Ming Li
Journal:  Biophys J       Date:  2004-02       Impact factor: 4.033

3.  Global rigid body modeling of macromolecular complexes against small-angle scattering data.

Authors:  Maxim V Petoukhov; Dmitri I Svergun
Journal:  Biophys J       Date:  2005-05-27       Impact factor: 4.033

4.  Structural themes and variations in protein kinase A as seen by small-angle scattering and neutron contrast variation.

Authors:  Jill Trewhella
Journal:  Eur Biophys J       Date:  2006-04-20       Impact factor: 1.733

5.  Joint use of small-angle X-ray and neutron scattering to study biological macromolecules in solution.

Authors:  Maxim V Petoukhov; Dmitri I Svergun
Journal:  Eur Biophys J       Date:  2006-04-25       Impact factor: 1.733

6.  Functional dynamics of the hydrophobic cleft in the N-domain of calmodulin.

Authors:  D Vigil; S C Gallagher; J Trewhella; A E García
Journal:  Biophys J       Date:  2001-05       Impact factor: 4.033

7.  Solution structure of the A4 domain of factor XI sheds light on the mechanism of zymogen activation.

Authors:  Dharmaraj Samuel; Hong Cheng; Paul W Riley; Adrian A Canutescu; Chandrasekaran Nagaswami; John W Weisel; Zimei Bu; Peter N Walsh; Heinrich Roder
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-20       Impact factor: 11.205

8.  The different views from small angles.

Authors:  Jill Trewhella
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-24       Impact factor: 11.205

9.  The roles of the RIIβ linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIβ protein kinase A: a small angle x-ray and neutron scattering study.

Authors:  Donald K Blumenthal; Jeffrey Copps; Eric V Smith-Nguyen; Ping Zhang; William T Heller; Susan S Taylor
Journal:  J Biol Chem       Date:  2014-08-11       Impact factor: 5.157

10.  Ca2+-induced structural changes in phosphorylase kinase detected by small-angle X-ray scattering.

Authors:  Timothy S Priddy; Brian A MacDonald; William T Heller; Owen W Nadeau; Jill Trewhella; Gerald M Carlson
Journal:  Protein Sci       Date:  2005-03-01       Impact factor: 6.725
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