F Maeda1, J P Keenan, A Pascual-Leone. 1. Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Cambridge, MA, USA.
Abstract
BACKGROUND: Neuroimaging studies of major depressive disorder (MDD) indicate interhemispheric differences in prefrontal cortical activity (right greater than left). AIMS: To investigate whether there are any interhemispheric differences of motor cortical excitability in MDD. METHOD: Eight patients with treatment-refractory MDD off medication were assessed for the severity of their depression, and transcranial magnetic stimulation studies (bilateral motor threshold and paired-pulse studies) were conducted. Eight normal controls were also studied. RESULTS: MDD patients showed significant interhemispheric differences in motor threshold and paired-pulse curves, both of which showed lower excitability on the left hemisphere. Such differences were absent in controls. CONCLUSIONS: Our findings may aid the further understanding of the neurophysiology underlying MDD.
BACKGROUND: Neuroimaging studies of major depressive disorder (MDD) indicate interhemispheric differences in prefrontal cortical activity (right greater than left). AIMS: To investigate whether there are any interhemispheric differences of motor cortical excitability in MDD. METHOD: Eight patients with treatment-refractory MDD off medication were assessed for the severity of their depression, and transcranial magnetic stimulation studies (bilateral motor threshold and paired-pulse studies) were conducted. Eight normal controls were also studied. RESULTS:MDDpatients showed significant interhemispheric differences in motor threshold and paired-pulse curves, both of which showed lower excitability on the left hemisphere. Such differences were absent in controls. CONCLUSIONS: Our findings may aid the further understanding of the neurophysiology underlying MDD.
Authors: A Münchau; J M Langosch; W Gerschlager; J C Rothwell; M Orth; M R Trimble Journal: J Neurol Neurosurg Psychiatry Date: 2005-04 Impact factor: 10.154
Authors: Amos D Korczyn; Steven C Schachter; Martin J Brodie; Sarang S Dalal; Jerome Engel; Alla Guekht; Hrvoje Hecimovic; Karim Jerbi; Andres M Kanner; Cecilie Johannessen Landmark; Pavel Mares; Petr Marusic; Stefano Meletti; Marco Mula; Philip N Patsalos; Markus Reuber; Philippe Ryvlin; Klára Štillová; Roberto Tuchman; Ivan Rektor Journal: Epilepsy Behav Date: 2013-06-10 Impact factor: 2.937