| Literature DB >> 11026485 |
W Danysz1, C G Parsons, G Quack.
Abstract
The previous overviews provided the basis for better therapeutic efficacy/tolerability of low to moderate affinity NMDA channel blockers. This prediction finds support in in vitro studies comparing protective and plasticity impairing effects (therapeutic vs. side-effect) of memantine and (+)MK-801. In fact it turned out that memantine had a far better therapeutic index. But can it be confirmed in the in vivo situation?Entities:
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Year: 2000 PMID： 11026485
Source DB: PubMed Journal: Amino Acids ISSN： 0939-4451 Impact factor: 3.520