Literature DB >> 11023982

Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury.

E Galun1, E Zeira, O Pappo, M Peters, S Rose-John.   

Abstract

The cytokine IL-6 plays a significant role in liver regeneration in conjunction with additional growth factors (HGF, TNF-alpha, and TGF-alpha). Many IL-6 effects depend on a naturally occurring soluble IL-6 receptor (sIL-6R). Here, the chimeric protein hyper-IL-6, constructed from the human IL-6 protein fused to a truncated form of its receptor, was found to have superagonistic IL-6 properties, and as such, enhanced liver cell regeneration. Hyper-IL-6 reversed the state of hepatotoxicity and enhanced the survival rates of rats suffering from fulminant hepatic failure after D-galactosamine administration. The hyper-IL-6 protein has a significant potential for use in the treatment of severe human liver diseases.

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Year:  2000        PMID： 11023982     DOI： 10.1096/fj.99-0913com

Source DB:  PubMed          Journal:  FASEB J        ISSN： 0892-6638            Impact factor:   5.191


  25 in total

1.  Hepatoprotection via the IL-6/Stat3 pathway.

Authors:  Rebecca Taub
Journal:  J Clin Invest       Date:  2003-10       Impact factor: 14.808

Review 2.  Interleukin-6 Family Cytokines.

Authors:  Stefan Rose-John
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-02-01       Impact factor: 10.005

3.  A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals.

Authors:  Cleide G da Silva; Peter Studer; Marco Skroch; Jerome Mahiou; Darlan C Minussi; Clayton R Peterson; Suzhuei W Wilson; Virendra I Patel; Averil Ma; Eva Csizmadia; Christiane Ferran
Journal:  Hepatology       Date:  2013-04-05       Impact factor: 17.425

4.  Epidermal growth factor receptor restoration rescues the fatty liver regeneration in mice.

Authors:  Teresa A Zimmers; Xiaoling Jin; Zongxiu Zhang; Yanlin Jiang; Leonidas G Koniaris
Journal:  Am J Physiol Endocrinol Metab       Date:  2017-06-27       Impact factor: 4.310

Review 5.  An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure.

Authors:  María-Jesús Tuñón; Marcelino Alvarez; Jesús-M Culebras; Javier González-Gallego
Journal:  World J Gastroenterol       Date:  2009-07-07       Impact factor: 5.742

6.  Role of the ¹³C-methacetin breath test in the assessment of acute liver injury in a rat model.

Authors:  Dong Zhu; Hui Zhang; Jing-Yi Mao; Hong-Yan Wang; Xin Li; You-Qing Xu
Journal:  World J Gastroenterol       Date:  2014-08-28       Impact factor: 5.742

7.  IL-6/IL-6R axis plays a critical role in acute kidney injury.

Authors:  Yael Nechemia-Arbely; Daniel Barkan; Galina Pizov; Anat Shriki; Stefan Rose-John; Eithan Galun; Jonathan H Axelrod
Journal:  J Am Soc Nephrol       Date:  2008-03-12       Impact factor: 10.121

8.  Enhancing or eliminating signals for cell survival to treat disease.

Authors:  David J Tweardy; Naijie Jing
Journal:  Trans Am Clin Climatol Assoc       Date:  2006

9.  Effects of Designer Hyper-Interleukin 11 (H11) on Hematopoiesis in Myelosuppressed Mice.

Authors:  Hanna Dams-Kozlowska; Eliza Kwiatkowska-Borowczyk; Katarzyna Gryska; Anna Lewandowska; Andrzej Marszalek; Sebastian Adamczyk; Anna Kowalik; Ewa Leporowska; Andrzej Mackiewicz
Journal:  PLoS One       Date:  2016-05-04       Impact factor: 3.240

10.  Signaling pathways involved in liver injury and regeneration in rabbit hemorrhagic disease, an animal model of virally-induced fulminant hepatic failure.

Authors:  Rodrigo García-Lastra; Beatriz San-Miguel; Irene Crespo; Francisco Jorquera; Marcelino Alvarez; Javier González-Gallego; María J Tuñón
Journal:  Vet Res       Date:  2009-09-03       Impact factor: 3.683
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