Literature DB >> 14523032

Hepatoprotection via the IL-6/Stat3 pathway.

Rebecca Taub1.   

Abstract

Stat3 is a vital transcription factor that is activated downstream of the gp130 receptor, primarily via IL-6 signaling in adult liver. A new study demonstrates that Stat3 provides hepatoprotection against Fas-mediated apoptotic liver damage by two mechanisms: direct inactivation of caspases and reduction of reactive oxygen species.

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Year:  2003        PMID： 14523032      PMCID： PMC198534          DOI： 10.1172/JCI19974

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  21 in total

Review 1.  Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.

Authors:  T Hirano; K Ishihara; M Hibi
Journal:  Oncogene       Date:  2000-05-15       Impact factor: 9.867

2.  Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo.

Authors:  M Ozaki; S S Deshpande; P Angkeow; J Bellan; C J Lowenstein; M C Dinauer; P J Goldschmidt-Clermont; K Irani
Journal:  FASEB J       Date:  2000-02       Impact factor: 5.191

3.  Rapid and specific reactive oxygen species generation via NADPH oxidase activation during Fas-mediated apoptosis.

Authors:  Y Suzuki; Y Ono; Y Hirabayashi
Journal:  FEBS Lett       Date:  1998-03-27       Impact factor: 4.124

4.  Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice.

Authors:  K Kovalovich; R A DeAngelis; W Li; E E Furth; G Ciliberto; R Taub
Journal:  Hepatology       Date:  2000-01       Impact factor: 17.425

Review 5.  Redox regulation of cellular activation.

Authors:  H Nakamura; K Nakamura; J Yodoi
Journal:  Annu Rev Immunol       Date:  1997       Impact factor: 28.527

Review 6.  Transcriptional regulatory signals define cytokine-dependent and -independent pathways in liver regeneration.

Authors:  R Taub; L E Greenbaum; Y Peng
Journal:  Semin Liver Dis       Date:  1999       Impact factor: 6.115

Review 7.  Fas and Fas ligand in gut and liver.

Authors:  M J Pinkoski; T Brunner; D R Green; T Lin
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2000-03       Impact factor: 4.052

8.  Dual mechanism of Fas-induced cell death in neuroglioma cells: a role for reactive oxygen species.

Authors:  S Jayanthi; S Ordonez; M T McCoy; J L Cadet
Journal:  Brain Res Mol Brain Res       Date:  1999-10-01

9.  Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation.

Authors:  S Grösch; G Fritz; B Kaina
Journal:  Cancer Res       Date:  1998-10-01       Impact factor: 12.701

10.  Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms.

Authors:  Sanae Haga; Keita Terui; Hui Qi Zhang; Shin Enosawa; Wataru Ogawa; Hiroshi Inoue; Torayuki Okuyama; Kiyoshi Takeda; Shizuo Akira; Tetsuya Ogino; Kaikobad Irani; Michitaka Ozaki
Journal:  J Clin Invest       Date:  2003-10       Impact factor: 14.808
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  62 in total

Review 1.  COX-2 in liver, from regeneration to hepatocarcinogenesis: what we have learned from animal models?

Authors:  Paloma Martín-Sanz; Rafael Mayoral; Marta Casado; Lisardo Boscá
Journal:  World J Gastroenterol       Date:  2010-03-28       Impact factor: 5.742

Review 2.  ALR and liver regeneration.

Authors:  Rafał Pawlowski; Jolanta Jura
Journal:  Mol Cell Biochem       Date:  2006-05-12       Impact factor: 3.396

3.  GABA, γ-Aminobutyric Acid, Protects Against Severe Liver Injury.

Authors:  Toshiyuki Hata; Fatima Rehman; Tomohide Hori; Justin H Nguyen
Journal:  J Surg Res       Date:  2018-12-17       Impact factor: 2.192

4.  Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection.

Authors:  Emilie A Bard-Chapeau; Jing Yuan; Nathalie Droin; Shinong Long; Eric E Zhang; Thanh V Nguyen; Gen-Sheng Feng
Journal:  Mol Cell Biol       Date:  2006-06       Impact factor: 4.272

5.  Cr(VI)-stimulated STAT3 tyrosine phosphorylation and nuclear translocation in human airway epithelial cells requires Lck.

Authors:  Kimberley A O'Hara; Rasilaben J Vaghjiani; Antonia A Nemec; Linda R Klei; Aaron Barchowsky
Journal:  Biochem J       Date:  2007-03-01       Impact factor: 3.857

6.  Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha.

Authors:  Ana Moran; Ayse Akcan Arikan; Mary-Ann A Mastrangelo; Yong Wu; Bi Yu; Valeria Poli; David J Tweardy
Journal:  Int J Clin Exp Med       Date:  2008-06-15

7.  Reduced antioxidant level and increased oxidative damage in intact liver lobes during ischaemia-reperfusion.

Authors:  László Váli; Gabriella Taba; Klára Szentmihályi; Hedvig Fébel; Tímea Kurucz; Zsolt Pallai; Péter Kupcsulik; Anna Blázovics
Journal:  World J Gastroenterol       Date:  2006-02-21       Impact factor: 5.742

8.  Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice.

Authors:  Vincent E de Meijer; Deanna Y Sverdlov; Yury Popov; Hau D Le; Jonathan A Meisel; Vânia Nosé; Detlef Schuppan; Mark Puder
Journal:  PLoS One       Date:  2010-06-25       Impact factor: 3.240

Review 9.  Therapeutic targets in rheumatoid arthritis: the interleukin-6 receptor.

Authors:  Jean-Michel Dayer; Ernest Choy
Journal:  Rheumatology (Oxford)       Date:  2009-10-23       Impact factor: 7.580

10.  Signaling pathways involved in liver injury and regeneration in rabbit hemorrhagic disease, an animal model of virally-induced fulminant hepatic failure.

Authors:  Rodrigo García-Lastra; Beatriz San-Miguel; Irene Crespo; Francisco Jorquera; Marcelino Alvarez; Javier González-Gallego; María J Tuñón
Journal:  Vet Res       Date:  2009-09-03       Impact factor: 3.683
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