| Literature DB >> 11023498 |
A J Pelletier1, L J van der Laan, P Hildbrand, M A Siani, D A Thompson, P E Dawson, B E Torbett, D R Salomon.
Abstract
The role of chemokine-matrix interactions in integrin-dependent T-cell migration was examined to address the critical question of how chemokines provide directional information. The chemokine SDF-1 alpha binds fibronectin (Fn) with a low nanomolar K(d) (equilibrium dissociation constant). SDF-1 alpha presented by Fn induced directed migration. Spatial concentration gradients of chemokine were not required to maintain directed migration. Fn-presented chemokine induced the polarization of cells, including the redistribution of the SDF-1 alpha receptor, to the basal surface and leading edge of the cell. A new model for directed migration is proposed in which the co-presentation of an adhesive matrix and chemokine provides the necessary positional information independent of a soluble spatial gradient. (Blood. 2000;96:2682-2690)Entities:
Mesh：
Substances：
Year: 2000 PMID： 11023498
Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113