Literature DB >> 25863056

A dynamic model of chemoattractant-induced cell migration.

Hao Yang1, Xue Gou2, Yong Wang3, Tarek M Fahmy4, Anskar Y-H Leung5, Jian Lu2, Dong Sun6.   

Abstract

Cell migration refers to a directional cell movement in response to chemoattractant stimulation. In this work, we developed a cell-migration model by mimicking in vivo migration using optically manipulated chemoattractant-loaded microsources. The model facilitates a quantitative characterization of the relationship among the protrusion force, cell motility, and chemoattractant gradient for the first time (to our knowledge). We verified the correctness of the model using migrating leukemia cancer Jurkat cells. The results show that one can achieve the ideal migrating capacity by choosing the appropriate chemoattractant gradient and concentration at the leading edge of the cell.
Copyright © 2015 Biophysical Society. Published by Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 25863056      PMCID： PMC4390825          DOI： 10.1016/j.bpj.2014.12.060

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  23 in total

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