Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Oxygenated chalcones and bischalcones as potential antimalarial agents.

Literature DB >> 11012019

Oxygenated chalcones and bischalcones as potential antimalarial agents.

V J Ram¹, A S Saxena, S Srivastava, S Chandra.

Abstract

Oxygenated chalcones (3a,b) and bischalcones (4a-j) have been synthesized and evaluated for antimalarial activity against chloroquine sensitive and resistant strains of Plasmodium berghei in mice. Some of the screened compounds, 3a, 4c, 4e, 4f and 4i, have shown significant activity at 100 mg/kg dose against sensitive strain.

Entities: Chemical Species

Mesh：

Substances：

Year: 2000 PMID： 11012019 DOI： 10.1016/s0960-894x(00)00409-1

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

Keyword Cloud
Cited

10 in total

1. 4'-Acetamidochalcone derivatives as potential antinociceptive agents.

Authors: Fátima de Campos-Buzzi; Pâmela Padaratz; Aleandra Vergilina Meira; Rogério Corrêa; Ricardo José Nunes; Valdir Cechinel-Filho
Journal: Molecules Date: 2007-04-30 Impact factor: 4.411

2. The antiparasitic compound licochalcone a is a potent echinocytogenic agent that modifies the erythrocyte membrane in the concentration range where antiplasmodial activity is observed.

Authors: Hanne L Ziegler; Harald S Hansen; Dan Staerk; Søren Brøgger Christensen; Henry Hägerstrand; Jerzy W Jaroszewski
Journal: Antimicrob Agents Chemother Date: 2004-10 Impact factor: 5.191

Oxygenated chalcones and bischalcones as potential antimalarial agents.

1. 4'-Acetamidochalcone derivatives as potential antinociceptive agents.

2. The antiparasitic compound licochalcone a is a potent echinocytogenic agent that modifies the erythrocyte membrane in the concentration range where antiplasmodial activity is observed.

3. (2E)-1-(3-Chloro-phen-yl)-3-(4-chloro-phen-yl)prop-2-en-1-one.

4. (2E)-1-(3-Chloro-phen-yl)-3-phenyl-prop-2-en-1-one.

5. (2E)-3-[4-(Dimethyl-amino)-phen-yl]-1-(4-fluoro-phen-yl)prop-2-en-1-one.

Review 6. Molecular targets and anticancer activity of quinoline-chalcone hybrids: literature review.

7. 4-Hy-droxy-6-methyl-3-[3-(thio-phen-2-yl)acrylo-yl]-2H-pyran-2-one.

8. Gene Expression Response of Trichophyton rubrum during Coculture on Keratinocytes Exposed to Antifungal Agents.

9. Crystal structure of (2E)-1-(4-hy-droxy-3-meth-oxy-phen-yl)-3-(4-hy-droxy-phen-yl)prop-2-en-1-one.

10. Crystal structure of (2E)-3-(3-eth-oxy-4-hy-droxy-phen-yl)-1-(4-hy-droxy-phen-yl)prop-2-en-1-one.