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Literature DB >> 1101031

Antimutator activity during mitosis by a meiotic mutant of yeast.

M S Esposito, M Bolotin-Fukuhara, R E Esposito.

Abstract

Diploids homozygous for the mutation spo7-1 do not exhibit net premeiotic DNA synthesis at 34 degrees C and are defective in commitment to recombination following exposure to sporulation medium. The spo7-1 mutation confers antimutator activity during mitosis at 34 degrees C, indicating that the SPO7 gene product is involved in both mitotic and premeiotic DNA metabolism. Strains bearing spo7-1 are slightly more sensitive to killing by ultraviolet light than the wild type but are proficient in UV induced mutation and mitotic intragenic recombination. The mitotic antimutator activity of spo7-1 is directed against a class of forward mutations known to occur more frequently during mitosis than meiosis.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1975 PMID： 1101031 DOI： 10.1007/bf00267991

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

22 in total

1. Different Rates of Spontaneous Mutation during Mitosis and Meiosis in Yeast.

Authors: G E Magni; R C Von Borstel
Journal: Genetics Date: 1962-08 Impact factor: 4.562

2. Sporulation in Saccharomyces cerevisiae: premeiotic DNA synthesis, readiness and commitment.

Authors: G Simchen; R Piñon; Y Salts
Journal: Exp Cell Res Date: 1972-11 Impact factor: 3.905

3. Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4.

Authors: N Muzyczka; R L Poland; M J Bessman
Journal: J Biol Chem Date: 1972-11-25 Impact factor: 5.157

4. Deoxyribonucleic acid polymerases from yeast. Further purification and characterization of DNA-dependent DNA polymerases A and B.

Authors: E Wintersberger
Journal: Eur J Biochem Date: 1974-12-16

5. Genes controlling meiosis and spore formation in yeast.

Authors: M S Esposito; R E Esposito
Journal: Genetics Date: 1974-09 Impact factor: 4.562

6. Amino acid replacements resulting from super-suppression of nonsense mutants of iso-1-cytochrome c from yeast.

Authors: R A Gilmore; J W Stewart; F Sherman
Journal: J Mol Biol Date: 1971-10-14 Impact factor: 5.469

7. The genetic control of sporulation in Saccharomyces. I. The isolation of temperature-sensitive sporulation-deficient mutants.

Authors: M S Esposito; R E Esposito
Journal: Genetics Date: 1969-01 Impact factor: 4.562

8. Mutagenesis of super-suppressors in yeast.

Authors: G E Magni; P P Puglisi
Journal: Cold Spring Harb Symp Quant Biol Date: 1966

9. Single-strand scissions of chromosomal DNA during commitment to recombination at meiosis.

Authors: G K Jacobson; R Pinon; R E Esposito; M S Esposito
Journal: Proc Natl Acad Sci U S A Date: 1975-05 Impact factor: 11.205

10. ORIGIN AND NATURE OF SPONTANEOUS MUTATIONS IN MEIOTIC ORGANISMS.

Authors: G E Magni
Journal: J Cell Comp Physiol Date: 1964-10

8 in total

1. Coupling of Saccharomyces cerevisiae early meiotic gene expression to DNA replication depends upon RPD3 and SIN3.

Authors: T M Lamb; A P Mitchell
Journal: Genetics Date: 2001-02 Impact factor: 4.562

2. The REC46 gene of Saccharomyces cerevisiae controls mitotic chromosomal stability, recombination and sporulation: cell-type and life cycle stage-specific expression of the rec46-1 mutation.

Authors: M S Esposito; D T Maleas; K A Bjornstad; L L Holbrook
Journal: Curr Genet Date: 1986 Impact factor: 3.886

Antimutator activity during mitosis by a meiotic mutant of yeast.

1. Different Rates of Spontaneous Mutation during Mitosis and Meiosis in Yeast.

2. Sporulation in Saccharomyces cerevisiae: premeiotic DNA synthesis, readiness and commitment.

3. Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4.

4. Deoxyribonucleic acid polymerases from yeast. Further purification and characterization of DNA-dependent DNA polymerases A and B.

5. Genes controlling meiosis and spore formation in yeast.

6. Amino acid replacements resulting from super-suppression of nonsense mutants of iso-1-cytochrome c from yeast.

7. The genetic control of sporulation in Saccharomyces. I. The isolation of temperature-sensitive sporulation-deficient mutants.

8. Mutagenesis of super-suppressors in yeast.

9. Single-strand scissions of chromosomal DNA during commitment to recombination at meiosis.

10. ORIGIN AND NATURE OF SPONTANEOUS MUTATIONS IN MEIOTIC ORGANISMS.

1. Coupling of Saccharomyces cerevisiae early meiotic gene expression to DNA replication depends upon RPD3 and SIN3.

2. The REC46 gene of Saccharomyces cerevisiae controls mitotic chromosomal stability, recombination and sporulation: cell-type and life cycle stage-specific expression of the rec46-1 mutation.

3. Antimutators of mitochondrial and nuclear DNA in Saccharomyces cerevisiae. Relationship with gamma-ray sensitivity.

4. Meiosis in Neurospora crassa. I. The isolation of recessive mutants defective in the production of viable ascospores.

5. Evidence for joint genic control of spontaneous mutation and genetic recombination during mitosis in Saccharomyces.

6. A conditional antimutator in E. coli.

7. Interaction of an antimutator gene with DNA repair pathways in Escherichia coli K-12.

8. Mutants of Escherichia coli with increased fidelity of DNA replication.