Literature DB >> 11000470

Enhancement of DNA vaccine potency by electroporation in vivo.

M Selby1, C Goldbeck, T Pertile, R Walsh, J Ulmer.   

Abstract

The potential of electric current-mediated delivery technology to enhance DNA delivery and DNA vaccine potency was evaluated. Higher levels of reporter gene expression were observed in muscle cells of mice inoculated with luciferase or beta-galactosidase DNA followed by the application of electrical current, compared with DNA injected with no current. Similarly, substantially higher levels of immune responses (up to 20-fold) were demonstrated in mice vaccinated with HIV gag DNA and electric current. These enhanced responses were observed after one or two inoculations, and were maintained for at least 12 weeks. Therefore, the present studies demonstrate the utility of electroporation for enhancement of DNA vaccine potency in animals.

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Year:  2000        PMID： 11000470     DOI： 10.1016/s0168-1656(00)00308-4

Source DB:  PubMed          Journal:  J Biotechnol        ISSN： 0168-1656            Impact factor:   3.307


  18 in total

1.  The effect of CTAB concentration in cationic PLG microparticles on DNA adsorption and in vivo performance.

Authors:  Manmohan Singh; Mildred Ugozzoli; Maylene Briones; Jina Kazzaz; Elawati Soenawan; Derek T O'Hagan
Journal:  Pharm Res       Date:  2003-02       Impact factor: 4.200

2.  Increased in vivo immunological potency of HB-110, a novel therapeutic HBV DNA vaccine, by electroporation.

Authors:  Chae Young Kim; Eun Sung Kang; Seon Beom Kim; Han Eol Kim; Jae Hoon Choi; Dong Sop Lee; Se Jin Im; Se Hwan Yang; Young Chul Sung; Byong Moon Kim; Byung Gee Kim
Journal:  Exp Mol Med       Date:  2008-12-31       Impact factor: 8.718

3.  Tolerability of intramuscular and intradermal delivery by CELLECTRA(®) adaptive constant current electroporation device in healthy volunteers.

Authors:  Malissa C Diehl; Jessica C Lee; Stephen E Daniels; Pablo Tebas; Amir S Khan; Mary Giffear; Niranjan Y Sardesai; Mark L Bagarazzi
Journal:  Hum Vaccin Immunother       Date:  2013-06-04       Impact factor: 3.452

4.  Antigen expression kinetics and immune responses of mice immunized with noninfectious simian-human immunodeficiency virus DNA.

Authors:  Ramakrishna Hegde; ZhenQian Liu; Glenn Mackay; Marilyn Smith; Yahia Chebloune; Opendra Narayan; Dinesh K Singh
Journal:  J Virol       Date:  2005-12       Impact factor: 5.103

5.  Repeated DNA therapeutic vaccination of chronically SIV-infected macaques provides additional virological benefit.

Authors:  Antonio Valentin; Agneta von Gegerfelt; Margherita Rosati; Georgios Miteloudis; Candido Alicea; Cristina Bergamaschi; Rashmi Jalah; Vainav Patel; Amir S Khan; Ruxandra Draghia-Akli; George N Pavlakis; Barbara K Felber
Journal:  Vaccine       Date:  2010-02-23       Impact factor: 3.641

Review 6.  DNA vaccines for HIV: challenges and opportunities.

Authors:  David A Hokey; David B Weiner
Journal:  Springer Semin Immunopathol       Date:  2006-10-10

7.  Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques.

Authors:  Amara Luckay; Maninder K Sidhu; Rune Kjeken; Shakuntala Megati; Siew-Yen Chong; Vidia Roopchand; Dorys Garcia-Hand; Rashed Abdullah; Ralph Braun; David C Montefiori; Margherita Rosati; Barbara K Felber; George N Pavlakis; Iacob Mathiesen; Zimra R Israel; John H Eldridge; Michael A Egan
Journal:  J Virol       Date:  2007-02-28       Impact factor: 5.103

8.  A therapeutic SIV DNA vaccine elicits T-cell immune responses, but no sustained control of viremia in SIVmac239-infected rhesus macaques.

Authors:  Jan zur Megede; Brigitte Sanders-Beer; Peter Silvera; Dawn Golightly; Abigail Bowlsbey; Diane Hebblewaite; Deborah Sites; Lourdes Nieves-Duran; Ranjana Srivastava; Gillis R Otten; Dietmar Rabussay; Lei Zhang; Jeffrey B Ulmer; Susan W Barnett; John J Donnelly
Journal:  AIDS Res Hum Retroviruses       Date:  2008-08       Impact factor: 2.205

9.  Optimization of skin electroporation in mice to increase tolerability of DNA vaccine delivery to patients.

Authors:  Anna-Karin Roos; Fredrik Eriksson; Derin C Walters; Pavel Pisa; Alan D King
Journal:  Mol Ther       Date:  2009-06-16       Impact factor: 11.454

10.  A single electroporation delivery of a DNA vaccine containing the hemagglutinin gene of Asian H5N1 avian influenza virus generated a protective antibody response in chickens against a North American virus strain.

Authors:  Oladele Ogunremi; John Pasick; Gary P Kobinger; Drew Hannaman; Yohannes Berhane; Alfonso Clavijo; Sylvia van Drunen Littel-van den Hurk
Journal:  Clin Vaccine Immunol       Date:  2013-01-30
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