Literature DB >> 10998540

The hyperphagic effect of nociceptin/orphanin FQ in rats.

C Polidori1, G de Caro, M Massi.   

Abstract

Nociceptin/orphanin FQ (NC), the endogenous ligand of the opioid receptor-like1 (ORL1) receptor, has been reported to stimulate feeding in rats. The present article reviews the studies so far published on the effect of NC on food intake and reports new findings concerning the sensitivity of brain regions to the hyperphagic effect of NC in rats. The results obtained indicate that the hypothalamic arcuate nucleus is the most sensitive site among the brain regions so far investigated. On the basis of these findings and of the neurochemical and electrophysiological effects of NC, possible mechanisms of action and possible interactions with other neurotransmitter systems affecting feeding are discussed.

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Year:  2000        PMID： 10998540     DOI： 10.1016/s0196-9781(00)00243-6

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  25 in total

1.  Inhibition of striatal and retinal dopamine release via nociceptin/orphanin FQ receptors.

Authors:  K Flau; A Redmer; S Liedtke; M Kathmann; E Schlicker
Journal:  Br J Pharmacol       Date:  2002-12       Impact factor: 8.739

2.  Heterodimerization of ORL1 and opioid receptors and its consequences for N-type calcium channel regulation.

Authors:  Rhian M Evans; Haitao You; Shahid Hameed; Christophe Altier; Alexandre Mezghrani; Emmanuel Bourinet; Gerald W Zamponi
Journal:  J Biol Chem       Date:  2009-11-03       Impact factor: 5.157

3.  Parsing the hedonic and motivational influences of nociceptin on feeding using licking microstructure analysis in mice.

Authors:  Ian A Mendez; Nigel T Maidment; Niall P Murphy
Journal:  Behav Pharmacol       Date:  2016-09       Impact factor: 2.293

4.  The design and synthesis of a novel quinolizidine template for potent opioid and opioid receptor-like (ORL1, NOP) receptor ligands.

Authors:  Ling Jong; Nurulain Zaveri; Lawrence Toll
Journal:  Bioorg Med Chem Lett       Date:  2004-01-05       Impact factor: 2.823

5.  Functional antagonism between nociceptin/orphanin FQ (N/OFQ) and corticotropin-releasing factor (CRF) in the rat brain: evidence for involvement of the bed nucleus of the stria terminalis.

Authors:  Donata Rodi; Silvia Zucchini; Michele Simonato; Carlo Cifani; Maurizio Massi; Carlo Polidori
Journal:  Psychopharmacology (Berl)       Date:  2007-11-07       Impact factor: 4.530

6.  Caloric restriction increases the sensitivity to the hyperphagic effect of nociceptin/orphanin FQ limiting its ability to reduce binge eating in female rats.

Authors:  Maria Vittoria Micioni Di Bonaventura; Massimo Ubaldi; Sonia Liberati; Roberto Ciccocioppo; Maurizio Massi; Carlo Cifani
Journal:  Psychopharmacology (Berl)       Date:  2013-03-02       Impact factor: 4.530

Review 7.  Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.

Authors:  Lawrence Toll; Michael R Bruchas; Girolamo Calo'; Brian M Cox; Nurulain T Zaveri
Journal:  Pharmacol Rev       Date:  2016-03-08       Impact factor: 25.468

8.  The effect of serotonergic system on nociceptin/orphanin FQ induced food intake in chicken.

Authors:  Morteza Zendehdel; Kasra Mokhtarpouriani; Vahab Babapour; Ali Baghbanzadeh; Maryam Pourrahimi; Shahin Hassanpour
Journal:  J Physiol Sci       Date:  2013-04-25       Impact factor: 2.781

9.  The bed nucleus is a neuroanatomical substrate for the anorectic effect of corticotropin-releasing factor and for its reversal by nociceptin/orphanin FQ.

Authors:  Roberto Ciccocioppo; Amalia Fedeli; Daina Economidou; Federica Policani; Friedbert Weiss; Maurizio Massi
Journal:  J Neurosci       Date:  2003-10-15       Impact factor: 6.167

10.  Nutritional state influences Nociceptin/Orphanin FQ peptide receptor expression in the dorsal raphe nucleus.

Authors:  Magdalena J Przydzial; Alastair S Garfield; Daniel D Lam; Stephen P Moore; Mark L Evans; Lora K Heisler
Journal:  Behav Brain Res       Date:  2009-09-16       Impact factor: 3.332
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