| Literature DB >> 14684324 |
Ling Jong1, Nurulain Zaveri, Lawrence Toll.
Abstract
A new class of high affinity opioid and opioid receptor-like receptor (ORL1 receptor, NOP receptor) ligands has been designed by conformational restriction of piperidine-based NOP receptor ligands, resulting in a novel quinolizidine scaffold. Different modifications of the pendant functional groups on the scaffold provide differential activities at the opioid and NOP receptors. While the conformational rigidity will provide an improved understanding of the NOP and opioid receptor binding pockets, these compounds also provide a new template for the design of novel opiate and NOP ligands.Entities:
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Year: 2004 PMID： 14684324 PMCID： PMC3851569 DOI： 10.1016/j.bmcl.2003.09.068
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823