Literature DB >> 10994806

Discovery of novel ansamycins possessing potent inhibitory activity in a cell-based oncostatin M signalling assay.

P Stead1, S Latif, A P Blackaby, P J Sidebottom, A Deakin, N L Taylor, P Life, J Spaull, F Burrell, R Jones, J Lewis, I Davidson, T Mander.   

Abstract

We describe the isolation and characterisation of novel non-benzoquinone ansamycin metabolites related to geldanamycin from a culture of Streptomyces sp. S6699. The compounds possess potent inhibitory activity in a cell-based assay measuring inhibition of oncostatin M signalling in a reporter cell line utilising a secreted placental alkaline phosphatase (sPAP) readout. In this paper we report the isolation and structure elucidation of the compounds and describe some of their biological properties.

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Year:  2000        PMID： 10994806     DOI： 10.7164/antibiotics.53.657

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  4 in total

1.  Identification of new geldanamycin derivatives from unexplored microbial culture extracts using a MS/MS library.

Authors:  Jae Kyoung Lee; Jae-Hyuk Jang; Dong-Jin Park; Chang-Jin Kim; Jong Seog Ahn; Bang Yeon Hwang; Young-Soo Hong
Journal:  J Antibiot (Tokyo)       Date:  2016-12-21       Impact factor: 2.649

2.  Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption.

Authors:  Andreas Rascher; Zhihao Hu; Greg O Buchanan; Ralph Reid; C Richard Hutchinson
Journal:  Appl Environ Microbiol       Date:  2005-08       Impact factor: 4.792

3.  Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.

Authors:  Iwona E Wrona; Alexander Gozman; Tony Taldone; Gabriela Chiosis; James S Panek
Journal:  J Org Chem       Date:  2010-05-07       Impact factor: 4.354

4.  Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin.

Authors:  Simone Eichner; Timo Eichner; Heinz G Floss; Jörg Fohrer; Edgar Hofer; Florenz Sasse; Carsten Zeilinger; Andreas Kirschning
Journal:  J Am Chem Soc       Date:  2012-01-10       Impact factor: 15.419
  4 in total

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