Literature DB >> 1099437

Evidence for a functional association of DNA synthesis with the membrane in mitochondria of Saccharomyces cerevisiae.

R M Hall, J S Mattick, S Marzuki, A W Linnane.   

Abstract

We have studied the effect of membrane fatty acid composition on replicative DNA synthetic activity in mitochondria isolated from Saccharomyces cerevisiae. Cells containing different levels of membrane unsaturated fatty acids were obtained by growth of a fatty acid desaturase mutant of Saccharomyces cerevisiae in glucose-limited chemostat cultures supplemented with various concentrations of Tween 80. Arrhenius plots of DNA synthetic activity in isolated mitochondria show a discrete discontinuity at specific temperature which are dependent on the membrane unsaturated fatty acid content of the mitochondria. This indicates a functional association of DNA replication with the mitochondrial membrane in Saccharomyces cerevisiae.

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Year:  1975        PMID： 1099437     DOI： 10.1007/bf00357539

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  10 in total

1.  Dynamics of lipids in membranes: Heterogeneity and the role of cholesterol.

Authors:  E Oldfield; D Chapman
Journal:  FEBS Lett       Date:  1972-07-01       Impact factor: 4.124

2.  Partial resolution of the enzymes catalyzing oxidative phosphorylation. I. Purification and properties of soluble dinitrophenol-stimulated adenosine triphosphatase.

Authors:  M E PULLMAN; H S PENEFSKY; A DATTA; E RACKER
Journal:  J Biol Chem       Date:  1960-11       Impact factor: 5.157

3.  Determination of serum proteins by means of the biuret reaction.

Authors:  A G GORNALL; C J BARDAWILL; M M DAVID
Journal:  J Biol Chem       Date:  1949-02       Impact factor: 5.157

4.  Induction of respiratory incompetent mutants by unsaturated fatty acid depletion in Saccharomyces cerevisiae.

Authors:  S Marzuki; R M Hall; A W Linnane
Journal:  Biochem Biophys Res Commun       Date:  1974-03-25       Impact factor: 3.575

Review 5.  Regulation of chromosome replication and the bacterial cell cycle.

Authors:  M L Pato
Journal:  Annu Rev Microbiol       Date:  1972       Impact factor: 15.500

Review 6.  The structure and function of chromatin.

Authors:  D E Comings
Journal:  Adv Hum Genet       Date:  1972

Review 7.  The influence of temperature-induced phase changes on the kinetics of respiratory and other membrane-associated enzyme systems.

Authors:  J K Raison
Journal:  J Bioenerg       Date:  1973-01

Review 8.  DNA replication.

Authors:  A Klein; F Bonhoeffer
Journal:  Annu Rev Biochem       Date:  1972       Impact factor: 23.643

9.  Further studies on mutants of Escherichia coli with growth selectively affected by fatty acids.

Authors:  S Paris; D Samuel; G Ailhaud
Journal:  Biochimie       Date:  1974       Impact factor: 4.079

10.  Biogenesis of mitchondria. Phospholipid synthesis in vitro by yeast mitochondrial and microsomal fractions.

Authors:  G S Cobon; P D Crowfoot; A W Linnane
Journal:  Biochem J       Date:  1974-11       Impact factor: 3.857
  10 in total
  9 in total

1.  Comparative studies of the effects of acridines and other petite inducing drugs on the mitochondrial genome of Saccharomyces cerevisiae.

Authors:  J S Mattick
Journal:  Mol Gen Genet       Date:  1977-04-29

2.  Yme2p is a mediator of nucleoid structure and number in mitochondria of the yeast Saccharomyces cerevisiae.

Authors:  Sujin Park; Theodor Hanekamp; Mary K Thorsness; Peter E Thorsness
Journal:  Curr Genet       Date:  2006-07-19       Impact factor: 3.886

3.  Biogenesis of mitochondria. XLII. Genetic analysis of the control of cellular mitochondrial DNA levels in Saccharomyces cerevisiae.

Authors:  R M Hall; P Nagley; A W Linnane
Journal:  Mol Gen Genet       Date:  1976-05-07

4.  Mitochondrial DNA replication in petite mutants of yeast: resistance to inhibition by ethidium bromide, berenil and euflavine.

Authors:  P Nagley; J S Mattick
Journal:  Mol Gen Genet       Date:  1977-04-29

5.  Replicative deoxyribonucleic acid synthesis in isolated mitochondria from Saccharomyces cerevisiae.

Authors:  J S Mattick; R M Hall
Journal:  J Bacteriol       Date:  1977-06       Impact factor: 3.490

6.  Regulation of yeast mitochondrial DNA synthesis. I. Analysis of a mutant conditionally deficient in mitochondrial DNA metabolism.

Authors:  B Y Rubin; J Blamire
Journal:  Mol Gen Genet       Date:  1977-11-04

7.  Biogenesis of mitochondria. 43. A comparative study of petite induction and inhibition of mitochondrial DNA replication in yeast by ethidium bromide and berenil.

Authors:  P Nagley; J S Mattick; R M Hall; A W Linnane
Journal:  Mol Gen Genet       Date:  1975-12-09

8.  The action of structural analogues of ethidium bromide on the mitochondrial genome of yeast.

Authors:  R M Hall; J S Mattick; P Nagley; G S Cobon; F W Eastwood; A W Linnane
Journal:  Mol Biol Rep       Date:  1977-12       Impact factor: 2.316

9.  Studies on the induction of petite mutants in yeast by analogues of berenil. Characterization of three mutants resistant to the compound Hoe 15,030.

Authors:  P R Vaughan; H Loewe; P Nagley
Journal:  Mol Gen Genet       Date:  1979
  9 in total

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