Literature DB >> 10993220

In vitro inhibitory effect of some flavonoids on rotavirus infectivity.

E A Bae1, M J Han, M Lee, D H Kim.   

Abstract

The inhibitory effects of some flavonoids on the infectivity of rotavirus, which predominantly causes sporadic diarrhea in infants and young children, were investigated. Among tested flavonoids, diosmin and hesperidin had the most potent inhibitory activity on rotavirus infection. The fifty percent inhibitory concentration of both compounds was 10 microM. However, their aglycones did not have the inhibitory activity. The rutinose moiety of flavonoids should protect against the invasion of rotavirus into cells.

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Year:  2000        PMID： 10993220     DOI： 10.1248/bpb.23.1122

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN： 0918-6158            Impact factor:   2.233


  25 in total

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