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Literature DB >> 10991876

Effect of subinhibitory concentrations of macrolides on expression of flagellin in Pseudomonas aeruginosa and Proteus mirabilis.

K Kawamura-Sato¹, Y Iinuma, T Hasegawa, T Horii, T Yamashino, M Ohta.

Abstract

In the present study we showed by molecular analysis that the inhibition of motility by macrolides in Proteus mirabilis and Pseudomonas aeruginosa was well correlated with the loss of the expression of flagellin. Erythromycin, clarithromycin, and azithromycin at subinhibitory concentrations (sub-MICs) suppressed the expression of flagellin dose dependently. Azithromycin had the strongest inhibitory effect on the expression of P. aeruginosa flagellin, whereas 16-membered rokitamycin had only a weak inhibitory effect. These results indicate the potential effectiveness of sub-MICs of erythromycin, clarithromycin, and azithromycin for the treatment of patients with P. mirabilis and P. aeruginosa infections.

Entities: Chemical Disease Species

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Year: 2000 PMID： 10991876 PMCID： PMC90167 DOI： 10.1128/AAC.44.10.2869-2872.2000

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

19 in total

1. Direct evidence for antipseudomonal activity of macrolides: exposure-dependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin, and azithromycin.

Authors: K Tateda; Y Ishii; T Matsumoto; N Furuya; M Nagashima; T Matsunaga; A Ohno; S Miyazaki; K Yamaguchi
Journal: Antimicrob Agents Chemother Date: 1996-10 Impact factor: 5.191

2. [The long term chemotherapy with erythromycin in chronic lower respiratory tract infections--second report: including cases with Pseudomonas infections].

Authors: M Sawaki; R Mikami; K Mikasa; M Kunimatsu; S Ito; N Narita
Journal: Kansenshogaku Zasshi Date: 1986-01

Review 3. Erythromycin.

Authors: M J Gribble; A W Chow
Journal: Med Clin North Am Date: 1982-01 Impact factor: 5.456

4. The influence of azithromycin on the biofilm formation of Pseudomonas aeruginosa in vitro.

Authors: T Ichimiya; K Takeoka; K Hiramatsu; K Hirai; T Yamasaki; M Nasu
Journal: Chemotherapy Date: 1996 May-Jun Impact factor: 2.544

5. Single-dose intrapulmonary pharmacokinetics of azithromycin, clarithromycin, ciprofloxacin, and cefuroxime in volunteer subjects.

Authors: J E Conte; J Golden; S Duncan; E McKenna; E Lin; E Zurlinden
Journal: Antimicrob Agents Chemother Date: 1996-07 Impact factor: 5.191

6. Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development.

Authors: G A O'Toole; R Kolter
Journal: Mol Microbiol Date: 1998-10 Impact factor: 3.501

7. Inhibition of motility of Pseudomonas aeruginosa and Proteus mirabilis by subinhibitory concentrations of azithromycin.

Authors: G Molinari; P Paglia; G C Schito
Journal: Eur J Clin Microbiol Infect Dis Date: 1992-05 Impact factor: 3.267

8. Inhibition of Pseudomonas aeruginosa virulence factors by subinhibitory concentrations of azithromycin and other macrolide antibiotics.

Authors: G Molinari; C A Guzmán; A Pesce; G C Schito
Journal: J Antimicrob Chemother Date: 1993-05 Impact factor: 5.790

9. Sequence and genetic analysis of multiple flagellin-encoding genes from Proteus mirabilis.

Authors: R Belas; D Flaherty
Journal: Gene Date: 1994-10-11 Impact factor: 3.688

10. Inhibition of Pseudomonas aeruginosa exoenzyme expression by subinhibitory antibiotic concentrations.

Authors: K Grimwood; M To; H R Rabin; D E Woods
Journal: Antimicrob Agents Chemother Date: 1989-01 Impact factor: 5.938

24 in total

1. Effect of Sub-MICs of Macrolides on the Sensitivity of Pseudomonas aeruginosa to Nitrosative Stress: Effectiveness against P. aeruginosa with and without Multidrug Resistance.

Authors: Takeshi Shimizu; Tohru Miyoshi-Akiyama; Kohei Ogura; Shota Murata; Shota Ishige; Kiyohiro Kai; Konosuke Mitsutsuka; Haruyoshi Tomita; Koichi Tanimoto; Akio Matsumoto
Journal: Antimicrob Agents Chemother Date: 2020-09-21 Impact factor: 5.191

2. Macrolide immunomodulation of chronic respiratory diseases.

Authors: Daniel P Healy
Journal: Curr Infect Dis Rep Date: 2007-01 Impact factor: 3.725

3. Synergistic activity of sub-inhibitory concentrations of curcumin with ceftazidime and ciprofloxacin against Pseudomonas aeruginosa quorum sensing related genes and virulence traits.

Authors: Shekoufeh Roudashti; Habib Zeighami; Hesam Mirshahabi; Shahin Bahari; Ali Soltani; Fakhri Haghi
Journal: World J Microbiol Biotechnol Date: 2017-02-10 Impact factor: 3.312

Effect of subinhibitory concentrations of macrolides on expression of flagellin in Pseudomonas aeruginosa and Proteus mirabilis.

1. Direct evidence for antipseudomonal activity of macrolides: exposure-dependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin, and azithromycin.

2. [The long term chemotherapy with erythromycin in chronic lower respiratory tract infections--second report: including cases with Pseudomonas infections].

Review 3. Erythromycin.

4. The influence of azithromycin on the biofilm formation of Pseudomonas aeruginosa in vitro.

5. Single-dose intrapulmonary pharmacokinetics of azithromycin, clarithromycin, ciprofloxacin, and cefuroxime in volunteer subjects.

6. Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development.

7. Inhibition of motility of Pseudomonas aeruginosa and Proteus mirabilis by subinhibitory concentrations of azithromycin.

8. Inhibition of Pseudomonas aeruginosa virulence factors by subinhibitory concentrations of azithromycin and other macrolide antibiotics.

9. Sequence and genetic analysis of multiple flagellin-encoding genes from Proteus mirabilis.

10. Inhibition of Pseudomonas aeruginosa exoenzyme expression by subinhibitory antibiotic concentrations.

1. Effect of Sub-MICs of Macrolides on the Sensitivity of Pseudomonas aeruginosa to Nitrosative Stress: Effectiveness against P. aeruginosa with and without Multidrug Resistance.

2. Macrolide immunomodulation of chronic respiratory diseases.

3. Synergistic activity of sub-inhibitory concentrations of curcumin with ceftazidime and ciprofloxacin against Pseudomonas aeruginosa quorum sensing related genes and virulence traits.

Review 4. Antibacterial and immunomodulatory properties of azithromycin treatment implications for periodontitis.

5. Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells.

6. Quorum-sensing antagonistic activities of azithromycin in Pseudomonas aeruginosa PAO1: a global approach.

Review 7. Inhaled Antibiotics for Gram-Negative Respiratory Infections.

Review 8. What's new in cystic fibrosis? From treating symptoms to correction of the basic defect.

Review 9. Is there a role for inhaled corticosteroids and macrolide therapy in bronchiectasis?

Review 10. Role of macrolide therapy in chronic obstructive pulmonary disease.