Literature DB >> 10987432

Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil.

I R Baxendale1, S V Ley.   

Abstract

Sildenafil 1 (Viagra), a well known and commercially important pharmaceutical drug, has been prepared using polymer-supported reagents in a multi-step, convergent process resulting in a clean and efficient preparation without the need for conventional purification methods.

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Year:  2000        PMID： 10987432     DOI： 10.1016/s0960-894x(00)00383-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  A simple and rapid protocol for the synthesis of phenacyl derivatives using macroporous polymer-supported reagents.

Authors:  Ali R Kiasat; Soheil Sayyahi
Journal:  Mol Divers       Date:  2009-09-11       Impact factor: 2.943

2.  Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 1. Sildenafil analogs.

Authors:  Cuihua Wang; Trent D Ashton; Alden Gustafson; Nicholas D Bland; Stefan O Ochiana; Robert K Campbell; Michael P Pollastri
Journal:  Bioorg Med Chem Lett       Date:  2012-02-09       Impact factor: 2.823

3.  Continuous flow based catch and release protocol for the synthesis of alpha-ketoesters.

Authors:  Alessandro Palmieri; Steven V Ley; Anastasios Polyzos; Mark Ladlow; Ian R Baxendale
Journal:  Beilstein J Org Chem       Date:  2009-05-20       Impact factor: 2.883

Review 4.  An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles.

Authors:  Marcus Baumann; Ian R Baxendale
Journal:  Beilstein J Org Chem       Date:  2013-10-30       Impact factor: 2.883

Review 5.  MAOS and medicinal chemistry: some important examples from the last years.

Authors:  Nailton M Nascimento-Júnior; Arthur E Kümmerle; Eliezer J Barreiro; Carlos A M Fraga
Journal:  Molecules       Date:  2011-11-07       Impact factor: 4.411

Review 6.  Polymer-supported triphenylphosphine: application in organic synthesis and organometallic reactions.

Authors:  Ziad Moussa; Zaher M A Judeh; Saleh A Ahmed
Journal:  RSC Adv       Date:  2019-11-05       Impact factor: 4.036

7.  Enaminonitriles in heterocyclic synthesis: a route to 1,3-diaryl-4-aminopyrazole derivatives.

Authors:  Hanadi Y Medrasi; Mariam Abdullah Al-Sheikh; Abdellatif Mohamed Salaheldin
Journal:  Molecules       Date:  2013-01-02       Impact factor: 4.411
  7 in total

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