| Literature DB >> 10987190 |
S A Almeida1, J M Teófilo, J A Anselmo Franci, L G Brentegani, T L Lamano-Carvalho.
Abstract
The purpose of the present study was to investigate whether treatment of male rats with the calcium antagonist amlodipine, used in the treatment of hypertension and angina, interferes with the reproductive function of male rats. Amlodipine treatment (0.04 mg amlodipine besylate/rat/day for 30 days) decreased plasma follicle-stimulating hormone and testosterone but not luteinizing hormone or prolactin concentrations (measured by double-antibody radioimmuno-assay). A significant reduction (23%) was observed in sperm density (sperm suspension collected from the cauda epididymidis) as well as in the amount of mature spermatids (14%) and Sertoli cells (9%) counted in seminiferous tubule cross-sections (400 x magnification). The results reveal the deleterious effects of subacute amlodipine treatment on the reproductive function of male rats.Entities:
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Year: 2000 PMID： 10987190 DOI： 10.1016/S0940-2993(00)80062-7
Source DB: PubMed Journal: Exp Toxicol Pathol ISSN： 0940-2993