Literature DB >> 10986700

Bioassay for tumor necrosis factors-alpha and -beta.

T J Evans1.   

Abstract

Tumor necrosis factor (TNF) is a central cytokine in the pathogenesis of septic shock and other inflammatory states. Assay by immunoassay is convenient, but, because of circulating soluble receptors, does not accurately reflect biological activity of the cytokine. This article describes how to perform a bioassay for TNF, using its cytopathic effect on the murine cell line L929. By suitable manipulation, the assay can determine the two different forms of TNF, alpha and beta.

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Year:  2000        PMID： 10986700     DOI： 10.1385/MB:15:3:243

Source DB:  PubMed          Journal:  Mol Biotechnol        ISSN： 1073-6085            Impact factor:   2.695


  9 in total

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Authors:  H Pfister; T Hennet; T W Jungi
Journal:  Immunology       Date:  1992-11       Impact factor: 7.397

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Journal:  Lancet       Date:  1996-11-09       Impact factor: 79.321

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Authors:  D A Flick; G E Gifford
Journal:  J Immunol Methods       Date:  1984-03-30       Impact factor: 2.303

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Authors:  G H Wong; J H Elwell; L W Oberley; D V Goeddel
Journal:  Cell       Date:  1989-09-08       Impact factor: 41.582

5.  Shock and tissue injury induced by recombinant human cachectin.

Authors:  K J Tracey; B Beutler; S F Lowry; J Merryweather; S Wolpe; I W Milsark; R J Hariri; T J Fahey; A Zentella; J D Albert
Journal:  Science       Date:  1986-10-24       Impact factor: 47.728

6.  Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease.

Authors:  A Waage; A Halstensen; T Espevik
Journal:  Lancet       Date:  1987-02-14       Impact factor: 79.321

7.  A specific and reliable bioassay for the detection of femtomolar levels of human and murine tumor necrosis factors.

Authors:  D R Branch; A Shah; L J Guilbert
Journal:  J Immunol Methods       Date:  1991-10-25       Impact factor: 2.303

8.  Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity.

Authors:  P W Gray; B B Aggarwal; C V Benton; T S Bringman; W J Henzel; J A Jarrett; D W Leung; B Moffat; P Ng; L P Svedersky
Journal:  Nature       Date:  1984 Dec 20-1985 Jan 2       Impact factor: 49.962

9.  Endotoxin-induced tumor necrosis factor.

Authors:  H F Oettgen; E A Carswell; R L Kassel; N Fiore; B Williamson; M K Hoffmann; K Haranaka; L J Old
Journal:  Recent Results Cancer Res       Date:  1980
  9 in total
  2 in total

1.  Cell wall-mediated neuronal damage in early sepsis.

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Journal:  Infect Immun       Date:  2006-07       Impact factor: 3.441

2.  Pharmacokinetic and Pharmacodynamic Characterisation of an Anti-Mouse TNF Receptor 1 Domain Antibody Formatted for In Vivo Half-Life Extension.

Authors:  Laura J Goodall; Milan Ovecka; Daniel Rycroft; Sarah L Friel; Andrew Sanderson; Prafull Mistry; Marie L Davies; A Allart Stoop
Journal:  PLoS One       Date:  2015-09-09       Impact factor: 3.240
  2 in total

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