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Literature DB >> 6334807

Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity.

P W Gray, B B Aggarwal, C V Benton, T S Bringman, W J Henzel, J A Jarrett, D W Leung, B Moffat, P Ng, L P Svedersky.

Abstract

A chemically-synthesized gene and natural complementary DNA coding for human lymphotoxin were isolated and engineered for expression in Escherichia coli. Purified recombinant lymphotoxin shows cytotoxic activity on murine and human tumour cell lines in vitro and causes necrosis of certain murine sarcomas in vivo.

Entities: Disease Gene Species

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Year: 1984 PMID： 6334807 DOI： 10.1038/312721a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

123 in total

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Journal: J Virol Date: 2001-01 Impact factor: 5.103

Review 2. Cytokines: past, present, and future.

Authors: J J Oppenheim
Journal: Int J Hematol Date: 2001-07 Impact factor: 2.490

3. Oncogene-driven intrinsic inflammation induces leukocyte production of tumor necrosis factor that critically contributes to mammary carcinogenesis.

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Journal: Cancer Res Date: 2010-10-05 Impact factor: 12.701

Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity.

1. Localization of the gD-binding region of the human herpes simplex virus receptor, HveA.

Review 2. Cytokines: past, present, and future.

3. Oncogene-driven intrinsic inflammation induces leukocyte production of tumor necrosis factor that critically contributes to mammary carcinogenesis.

4. Critical role of the C-terminus in the biological activities of human tumour necrosis factor-alpha.

Review 5. Polypeptides controlling hematopoietic cell development and activation. I. In vitro results.

6. Enhancement of human immunodeficiency virus production by natural lymphotoxin.

7. Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha.

8. Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor.

9. Release of cytokines during generation of lymphokine-activated killer (LAK) cells by IL-2.

Review 10. The role of lymphotoxin-α in rheumatoid arthritis.