Literature DB >> 10986270

Bacillus subtilis ccpA gene mutants specifically defective in activation of acetoin biosynthesis.

A J Turinsky1, T R Moir-Blais, F J Grundy, T M Henkin.   

Abstract

A large number of carbon source utilization pathways are repressed in Bacillus subtilis by the global regulator CcpA, which also acts as an activator of carbon excretion pathways during growth in media containing glucose. In this study, CcpA mutants defective in transcriptional activation of the alsSD operon, which is involved in acetoin biosynthesis, were identified. These mutants retained normal glucose repression of amyE, encoding alpha-amylase, and acsA, encoding acetyl-coenzyme A synthetase, and normal activation of ackA, which is involved in acetate excretion; in these ccpA mutants the CcpA functions of activation of the acetate and acetoin excretion pathways appear to be separated.

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Year:  2000        PMID： 10986270      PMCID： PMC111010          DOI： 10.1128/JB.182.19.5611-5614.2000

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  22 in total

1.  Site-directed mutagenesis of a catabolite repression operator sequence in Bacillus subtilis.

Authors:  M J Weickert; G H Chambliss
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

2.  A novel protein kinase that controls carbon catabolite repression in bacteria.

Authors:  J Reizer; C Hoischen; F Titgemeyer; C Rivolta; R Rabus; J Stülke; D Karamata; M H Saier; W Hillen
Journal:  Mol Microbiol       Date:  1998-03       Impact factor: 3.501

3.  Catabolic repression of bacterial sporulation.

Authors:  P Schaeffer; J Millet; J P Aubert
Journal:  Proc Natl Acad Sci U S A       Date:  1965-09       Impact factor: 11.205

4.  The Bacillus subtilis crh gene encodes a HPr-like protein involved in carbon catabolite repression.

Authors:  A Galinier; J Haiech; M C Kilhoffer; M Jaquinod; J Stülke; J Deutscher; I Martin-Verstraete
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-05       Impact factor: 11.205

5.  Catabolite regulation of the pta gene as part of carbon flow pathways in Bacillus subtilis.

Authors:  E Presecan-Siedel; A Galinier; R Longin; J Deutscher; A Danchin; P Glaser; I Martin-Verstraete
Journal:  J Bacteriol       Date:  1999-11       Impact factor: 3.490

6.  Identification of a co-repressor binding site in catabolite control protein CcpA.

Authors:  A Kraus; E Küster; A Wagner; K Hoffmann; W Hillen
Journal:  Mol Microbiol       Date:  1998-12       Impact factor: 3.501

7.  Catabolite repression of alpha-amylase gene expression in Bacillus subtilis involves a trans-acting gene product homologous to the Escherichia coli lacl and galR repressors.

Authors:  T M Henkin; F J Grundy; W L Nicholson; G H Chambliss
Journal:  Mol Microbiol       Date:  1991-03       Impact factor: 3.501

8.  Glutamine synthetase gene of Bacillus subtilis.

Authors:  S H Fisher; M S Rosenkrantz; A L Sonenshein
Journal:  Gene       Date:  1984-12       Impact factor: 3.688

Review 9.  The role of CcpA transcriptional regulator in carbon metabolism in Bacillus subtilis.

Authors:  T M Henkin
Journal:  FEMS Microbiol Lett       Date:  1996-01-01       Impact factor: 2.742

10.  Transcriptional activation of the Bacillus subtilis ackA gene requires sequences upstream of the promoter.

Authors:  A J Turinsky; F J Grundy; J H Kim; G H Chambliss; T M Henkin
Journal:  J Bacteriol       Date:  1998-11       Impact factor: 3.490
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  8 in total

Review 1.  The acetate switch.

Authors:  Alan J Wolfe
Journal:  Microbiol Mol Biol Rev       Date:  2005-03       Impact factor: 11.056

Review 2.  How phosphotransferase system-related protein phosphorylation regulates carbohydrate metabolism in bacteria.

Authors:  Josef Deutscher; Christof Francke; Pieter W Postma
Journal:  Microbiol Mol Biol Rev       Date:  2006-12       Impact factor: 11.056

3.  Regulators of the Bacillus subtilis cydABCD operon: identification of a negative regulator, CcpA, and a positive regulator, ResD.

Authors:  Ankita Puri-Taneja; Matthew Schau; Yinghua Chen; F Marion Hulett
Journal:  J Bacteriol       Date:  2007-02-23       Impact factor: 3.490

4.  CcpA causes repression of the phoPR promoter through a novel transcription start site, P(A6).

Authors:  Ankita Puri-Taneja; Salbi Paul; Yinghua Chen; F Marion Hulett
Journal:  J Bacteriol       Date:  2006-02       Impact factor: 3.490

5.  Functional genomics approach to identifying genes required for biofilm development by Streptococcus mutans.

Authors:  Zezhang T Wen; Robert A Burne
Journal:  Appl Environ Microbiol       Date:  2002-03       Impact factor: 4.792

6.  Interplay of CodY and CcpA in Regulating Central Metabolism and Biofilm Formation in Staphylococcus aureus.

Authors:  Logan L Bulock; Jongsam Ahn; Dhananjay Shinde; Sanjit Pandey; Cleofes Sarmiento; Vinai C Thomas; Chittibabu Guda; Kenneth W Bayles; Marat R Sadykov
Journal:  J Bacteriol       Date:  2022-06-23       Impact factor: 3.476

7.  Heavy involvement of stringent transcription control depending on the adenine or guanine species of the transcription initiation site in glucose and pyruvate metabolism in Bacillus subtilis.

Authors:  Shigeo Tojo; Kanako Kumamoto; Kazutake Hirooka; Yasutaro Fujita
Journal:  J Bacteriol       Date:  2010-01-15       Impact factor: 3.490

8.  In Bacillus subtilis, the sirtuin protein deacetylase, encoded by the srtN gene (formerly yhdZ), and functions encoded by the acuABC genes control the activity of acetyl coenzyme A synthetase.

Authors:  Jeffrey G Gardner; Jorge C Escalante-Semerena
Journal:  J Bacteriol       Date:  2009-01-09       Impact factor: 3.490
  8 in total

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