Literature DB >> 8598282

The role of CcpA transcriptional regulator in carbon metabolism in Bacillus subtilis.

T M Henkin1.   

Abstract

The CcpA protein has been identified as a key regulator of carbon metabolism in Bacillus subtilis. CcpA is a DNA binding protein in the LacI/GalR transcriptional repressor family, and genes which respond to CcpA contain common cis-acting target sequences (Ccp boxes). A number of pathways involved in carbon source utilization are repressed by CcpA, while at least one gene which is involved in excretion of excess carbon is activated by CcpA. Genes repressed by CcpA generally contain Ccp boxes within or downstream of the promoter, while ackA, which is activated by CcpA, contains Ccp boxes upstream of the promoter. It therefore appears that CcpA acts globally to direct carbon flow in B. subtilis.

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Year:  1996        PMID： 8598282     DOI： 10.1111/j.1574-6968.1996.tb07959.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  81 in total

1.  Control of lactose transport, beta-galactosidase activity, and glycolysis by CcpA in Streptococcus thermophilus: evidence for carbon catabolite repression by a non-phosphoenolpyruvate-dependent phosphotransferase system sugar.

Authors:  P T van den Bogaard; M Kleerebezem; O P Kuipers; W M de Vos
Journal:  J Bacteriol       Date:  2000-11       Impact factor: 3.490

2.  Regulation of the acetoin catabolic pathway is controlled by sigma L in Bacillus subtilis.

Authors:  N O Ali; J Bignon; G Rapoport; M Debarbouille
Journal:  J Bacteriol       Date:  2001-04       Impact factor: 3.490

3.  Structure of the effector-binding domain of the arabinose repressor AraR from Bacillus subtilis.

Authors:  Kateřina Procházková; Kateřina Cermáková; Petr Pachl; Irena Sieglová; Milan Fábry; Zbyszek Otwinowski; Pavlína Rezáčová
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2012-01-17

Review 4.  The acetate switch.

Authors:  Alan J Wolfe
Journal:  Microbiol Mol Biol Rev       Date:  2005-03       Impact factor: 11.056

5.  Catabolite control protein A (CcpA) contributes to virulence and regulation of sugar metabolism in Streptococcus pneumoniae.

Authors:  Ramkumar Iyer; Nitin S Baliga; Andrew Camilli
Journal:  J Bacteriol       Date:  2005-12       Impact factor: 3.490

6.  An intergenic stem-loop mutation in the Bacillus subtilis ccpA-motPS operon increases motPS transcription and the MotPS contribution to motility.

Authors:  Naoya Terahara; Makoto Fujisawa; Benjamin Powers; Tina M Henkin; Terry A Krulwich; Masahiro Ito
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490

7.  CcpC-dependent regulation of citrate synthase gene expression in Listeria monocytogenes.

Authors:  Meghna Mittal; Silvia Picossi; Abraham L Sonenshein
Journal:  J Bacteriol       Date:  2008-11-14       Impact factor: 3.490

8.  Crystal structures of the effector-binding domain of repressor Central glycolytic gene Regulator from Bacillus subtilis reveal ligand-induced structural changes upon binding of several glycolytic intermediates.

Authors:  Pavlína Rezácová; Milan Kozísek; Shiu F Moy; Irena Sieglová; Andrzej Joachimiak; Mischa Machius; Zbyszek Otwinowski
Journal:  Mol Microbiol       Date:  2008-06-28       Impact factor: 3.501

9.  Catabolite regulation of the Bacillus subtilis ctaBCDEF gene cluster.

Authors:  X Liu; H W Taber
Journal:  J Bacteriol       Date:  1998-12       Impact factor: 3.490

10.  A homolog of CcpA mediates catabolite control in Listeria monocytogenes but not carbon source regulation of virulence genes.

Authors:  J Behari; P Youngman
Journal:  J Bacteriol       Date:  1998-12       Impact factor: 3.490
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