Literature DB >> 10981627

Advances in zinc finger engineering.

Y Choo1, M Isalan.   

Abstract

Recently developments have been made in engineering sequence-specific zinc finger DNA-binding proteins. Advances in this area will soon make it routine to target proteins to specific DNA sequences associated with any given gene. The primary interest is in the regulation of gene expression using customised transcription factors. However, modular catalytic domains are also being developed in order to engineer chimaeric proteins with customised restriction enzyme, methylase and integrase activity.

Mesh：

Year:  2000        PMID： 10981627     DOI： 10.1016/s0959-440x(00)00107-x

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  19 in total

Review 1.  Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities.

Authors:  Taco G Uil; Hidde J Haisma; Marianne G Rots
Journal:  Nucleic Acids Res       Date:  2003-11-01       Impact factor: 16.971

2.  Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors.

Authors:  Lindsey Reynolds; Christopher Ullman; Michael Moore; Mark Isalan; Michelle J West; Paul Clapham; Aaron Klug; Yen Choo
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-06       Impact factor: 11.205

Review 3.  The New State of the Art: Cas9 for Gene Activation and Repression.

Authors:  Marie F La Russa; Lei S Qi
Journal:  Mol Cell Biol       Date:  2015-09-14       Impact factor: 4.272

4.  Balancing between affinity and speed in target DNA search by zinc-finger proteins via modulation of dynamic conformational ensemble.

Authors:  Levani Zandarashvili; Alexandre Esadze; Dana Vuzman; Catherine A Kemme; Yaakov Levy; Junji Iwahara
Journal:  Proc Natl Acad Sci U S A       Date:  2015-08-31       Impact factor: 11.205

5.  A free-energy approach for all-atom protein simulation.

Authors:  Abhinav Verma; Wolfgang Wenzel
Journal:  Biophys J       Date:  2009-05-06       Impact factor: 4.033

Review 6.  Homeodomain revisited: a lesson from disease-causing mutations.

Authors:  Young-In Chi
Journal:  Hum Genet       Date:  2005-02-23       Impact factor: 4.132

Review 7.  Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers.

Authors:  Asuka Eguchi; Garrett O Lee; Fang Wan; Graham S Erwin; Aseem Z Ansari
Journal:  Biochem J       Date:  2014-09-15       Impact factor: 3.857

8.  Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors.

Authors:  Monika Papworth; Michael Moore; Mark Isalan; Michal Minczuk; Yen Choo; Aaron Klug
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-06       Impact factor: 11.205

9.  Evolutionary innovations and the organization of protein functions in genotype space.

Authors:  Evandro Ferrada; Andreas Wagner
Journal:  PLoS One       Date:  2010-11-30       Impact factor: 3.240

Review 10.  Designed transcription factors as structural, functional and therapeutic probes of chromatin in vivo. Fourth in review series on chromatin dynamics.

Authors:  Fyodor D Urnov; Edward J Rebar; Andreas Reik; Pier Paolo Pandolfi
Journal:  EMBO Rep       Date:  2002-07       Impact factor: 8.807
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