Literature DB >> 1098149

Glucagon release: paradoxical stimulation by glucose during calcium deprivation.

V Leclercq-Meyer, O Rebelledo, J Marchand, W Malaisse.   

Abstract

During calsium deprivation, the rate of glucagon release by the isolated perfused rat pancreas is positively related to the glucose concentration of the perfusion medium. It is suggested that such a paradoxical behavior, which is reminiscent of the abnormality of glucagon secretion recently disclosed in diabetic subjects, results from a perturbation in the normal structural and functional bridging between pancreatic alpha and beta cells.

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Year:  1975        PMID： 1098149     DOI： 10.1126/science.1098149

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  A combined radioimmunoassay for glucagon and insulin.

Authors:  V Leclercq-Meyer; J Marchand; O Rebolledo; W J Malaisse; R Leclercq
Journal:  Diabetologia       Date:  1975-10       Impact factor: 10.122

2.  The role of calcium in glucagon release, interactions between glucose and calcium.

Authors:  V Leclercq-Meyer; J Marchand; W J Malaisse
Journal:  Diabetologia       Date:  1976-10       Impact factor: 10.122

3.  Calcium, glucose and glucagon release.

Authors:  J Iversen; K Hermansen
Journal:  Diabetologia       Date:  1977-08       Impact factor: 10.122

4.  Glucagon and insulin secretion during acid-base alterations.

Authors:  O R Rebolledo; J J Gagliardino
Journal:  Acta Diabetol Lat       Date:  1983 Jul-Sep

Review 5.  Regulation of α-cell glucagon secretion: The role of second messengers.

Authors:  Samuel Acreman; Quan Zhang
Journal:  Chronic Dis Transl Med       Date:  2022-03-06

6.  Calcium antagonists and islet function: VII. Effect of calcium deprivation.

Authors:  W J Malaisse; J C Hutton; A Sener; J Levy; A Herchuelz; G Devis; G Somers
Journal:  J Membr Biol       Date:  1978-01-18       Impact factor: 1.843

7.  Calcium induced glucagon release in monolayer culture of the endocrine pancreas. Studies with ionophore A23187.

Authors:  C B Wollheim; B Blondel; A E Renold; G W Sharp
Journal:  Diabetologia       Date:  1976-08       Impact factor: 10.122

8.  Glucagon release from rat pancreatic islets. A combined morphological and functional approach.

Authors:  J L Carpentier; F Malaisse-Lagae; W A Müller
Journal:  J Clin Invest       Date:  1977-11       Impact factor: 14.808

9.  A new benzothiadiazine derivative, LN 5330: effects on pancreatic hormones.

Authors:  D Hillaire-Buys; G Ribes; J P Blayac; M M Loubatières-Mariani
Journal:  Diabetologia       Date:  1984-12       Impact factor: 10.122
  9 in total

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