Literature DB >> 10978536

Brain-specific expression of a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T9).

S Toba1, M Tenno, M Konishi, T Mikami, N Itoh, A Kurosaka.   

Abstract

We isolated cDNA coding for the ninth of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases (GalNAc-T9) from human brain by the polymerase chain reaction. The polypeptide encoded by GalNAc-T9 contained the structural features characteristic of GalNAc transferases, such as a GT1 motif, a Gal/GalNAc transferase motif, (QXW)(3) repeats, and conserved His, Cys, and acidic amino acid residues. Northern blot analysis revealed the mRNA expression of the enzyme to be confined to the brain. The brain-specific expression of GalNAc-T9 suggested that this isozyme catalyzes O-glycosylation in the brain.

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Year:  2000        PMID： 10978536     DOI： 10.1016/s0167-4781(00)00180-9

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  18 in total

1.  Glycopeptide N-acetylgalactosaminyltransferase specificities for O-glycosylated sites on MUC5AC mucin motif peptides.

Authors:  D Tetaert; K G Ten Hagen; C Richet; A Boersma; J Gagnon; P Degand
Journal:  Biochem J       Date:  2001-07-01       Impact factor: 3.857

2.  UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree.

Authors:  Jayalakshmi Raman; Yu Guan; Cynthia L Perrine; Thomas A Gerken; Lawrence A Tabak
Journal:  Glycobiology       Date:  2011-12-20       Impact factor: 4.313

Review 3.  Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family.

Authors:  Eric P Bennett; Ulla Mandel; Henrik Clausen; Thomas A Gerken; Timothy A Fritz; Lawrence A Tabak
Journal:  Glycobiology       Date:  2011-12-18       Impact factor: 4.313

Review 4.  Human airway mucin glycosylation: a combinatory of carbohydrate determinants which vary in cystic fibrosis.

Authors:  G Lamblin; S Degroote; J M Perini; P Delmotte; A Scharfman; M Davril; J M Lo-Guidice; N Houdret; V Dumur; A Klein; P Rousse
Journal:  Glycoconj J       Date:  2001-09       Impact factor: 2.916

5.  Conservation of peptide acceptor preferences between Drosophila and mammalian polypeptide-GalNAc transferase ortholog pairs.

Authors:  Thomas A Gerken; Kelly G Ten Hagen; Oliver Jamison
Journal:  Glycobiology       Date:  2008-07-31       Impact factor: 4.313

6.  N-Acetylgalactosaminyltransferase-14 as a potential biomarker for breast cancer by immunohistochemistry.

Authors:  Chen Wu; Xiaodan Guo; Weina Wang; Yun Wang; Yaojun Shan; Bo Zhang; Wenqian Song; Sisi Ma; Jianfeng Ge; Hao Deng; Mingsheng Zhu
Journal:  BMC Cancer       Date:  2010-04-01       Impact factor: 4.430

Review 7.  Recent insights into the biological roles of mucin-type O-glycosylation.

Authors:  E Tian; Kelly G Ten Hagen
Journal:  Glycoconj J       Date:  2008-08-10       Impact factor: 2.916

8.  Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus.

Authors:  Teresa Freire; Cecilia Fernández; Cora Chalar; Rick M Maizels; Pedro Alzari; Eduardo Osinaga; Carlos Robello
Journal:  Biochem J       Date:  2004-09-01       Impact factor: 3.857

Review 9.  Construction of a human glycogene library and comprehensive functional analysis.

Authors:  Hisashi Narimatsu
Journal:  Glycoconj J       Date:  2004       Impact factor: 2.916

10.  Loss of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 and reduced O-glycosylation in colon carcinoma cells selected for hepatic metastasis.

Authors:  Kentaro Kato; Hideyuki Takeuchi; Akira Kanoh; Naoki Miyahara; Yoko Nemoto-Sasaki; Megumi Morimoto-Tomita; Azusa Matsubara; Yoshimi Ohashi; Michihiko Waki; Katsuaki Usami; Ulla Mandel; Henrik Clausen; Nobuaki Higashi; Tatsuro Irimura
Journal:  Glycoconj J       Date:  2010-02       Impact factor: 2.916
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