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Literature DB >> 10978359

Genetics of club foot in Maori and Pacific people.

C Chapman¹, N S Stott, R V Port, R O Nicol.

Abstract

The role of major gene and multifactorial inheritance in the aetiology of club foot in the New Zealand Polynesian population was studied using 287 New Zealand Maori and Pacific club foot families. The club foot family data were analysed by complex segregation analysis under the mixed model using the computer program POINTER. This analysis shows that the best genetic model for club foot in this population is a single dominant gene with a penetrance of 33% and a predicted gene frequency of 0.9%. These data provide a scientific foundation for molecular studies in the Maori and Polynesian population to identify putative club foot genes.

Entities: Disease Species

Mesh：

Year: 2000 PMID： 10978359 PMCID： PMC1734697 DOI： 10.1136/jmg.37.9.680

Source DB: PubMed Journal: J Med Genet ISSN： 0022-2593 Impact factor: 6.318

13 in total

1. Segregation analysis of idiopathic talipes equinovarus in a Texan population.

Authors: M de Andrade; J S Barnholtz; C I Amos; C Lochmiller; A Scott; M Risman; J T Hecht
Journal: Am J Med Genet Date: 1998-09-01

2. The role of major gene in clubfoot.

Authors: J H Wang; R M Palmer; C S Chung
Journal: Am J Hum Genet Date: 1988-05 Impact factor: 11.025

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Authors: H Y Yang; C S Chung; R W Nemechek
Journal: Genet Epidemiol Date: 1987 Impact factor: 2.135

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Authors: F R Dietz
Journal: Lancet Date: 1985-02-16 Impact factor: 79.321

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Authors: D I Brougham; R O Nicol
Journal: J Pediatr Orthop Date: 1988 Nov-Dec Impact factor: 2.324

6. A single-gene explanation for the probability of having idiopathic talipes equinovarus.

Authors: T R Rebbeck; F R Dietz; J C Murray; K H Buetow
Journal: Am J Hum Genet Date: 1993-11 Impact factor: 11.025

7. Observations on the epidemiology of club foot in Polynesian and Caucasian populations.

Authors: I Cartlidge
Journal: J Med Genet Date: 1984-08 Impact factor: 6.318

8. Estimation of demographic parameters from isolation by distance.

Authors: N E Morton
Journal: Hum Hered Date: 1982 Impact factor: 0.444

9. Club foot in the Maori: a genetic study of 50 kindreds.

Authors: R K Beals
Journal: N Z Med J Date: 1978-08-23

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Authors: I J Cartlidge
Journal: N Z Med J Date: 1983-07-13

24 in total

Review 1. Update on clubfoot: etiology and treatment.

Authors: Matthew B Dobbs; Christina A Gurnett
Journal: Clin Orthop Relat Res Date: 2009-02-18 Impact factor: 4.176

2. Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot.

Authors: William Shyy; Kai Wang; Val C Sheffield; Jose A Morcuende
Journal: J Pediatr Orthop Date: 2010 Apr-May Impact factor: 2.324

3. Copy number analysis of 413 isolated talipes equinovarus patients suggests role for transcriptional regulators of early limb development.

Authors: David M Alvarado; Jillian G Buchan; Steven L Frick; John E Herzenberg; Matthew B Dobbs; Christina A Gurnett
Journal: Eur J Hum Genet Date: 2012-08-15 Impact factor: 4.246

Genetics of club foot in Maori and Pacific people.

1. Segregation analysis of idiopathic talipes equinovarus in a Texan population.

2. The role of major gene in clubfoot.

3. A genetic analysis of clubfoot in Hawaii.

4. On the pathogenesis of clubfoot.

5. Use of the Cincinnati incision in congenital talipes equinovarus.

6. A single-gene explanation for the probability of having idiopathic talipes equinovarus.

7. Observations on the epidemiology of club foot in Polynesian and Caucasian populations.

8. Estimation of demographic parameters from isolation by distance.

9. Club foot in the Maori: a genetic study of 50 kindreds.

10. Club foot in the Polynesian: an epidemiological survey.

Review 1. Update on clubfoot: etiology and treatment.

2. Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot.

3. Copy number analysis of 413 isolated talipes equinovarus patients suggests role for transcriptional regulators of early limb development.

Review 4. Congenital talipes equinovarus (clubfoot): a disorder of the foot but not the hand.

5. Apoptotic genes expression in placenta of clubfoot-like fetus pregnant rats.

6. Polygenic threshold model with sex dimorphism in clubfoot inheritance: the Carter effect.

7. Celsr3 is required in motor neurons to steer their axons in the hindlimb.

8. Congenital talipes equinovarus in Papua New Guinea: a difficult yet potentially manageable situation.

9. Evaluation of CAND2 and WNT7a as candidate genes for congenital idiopathic clubfoot.

10. The expression of Gli3, regulated by HOXD13, may play a role in idiopathic congenital talipes equinovarus.