Literature DB >> 280791

Club foot in the Maori: a genetic study of 50 kindreds.

R K Beals.   

Abstract

A genetic study of 50 Maori kindreds suggests club foot to be inherited as a polygenic trait as in Caucasians. A higher incidence of right foot involvement was present in the Maori. Empiric risk data indicated that if the index patient was female, the chance of subsequent children being affected was four percent. If the index patient was male, the chance of subsequent children being affected was nine percent, and if parent and child were affected, the chance of subsequent children being affected was 30 percent. These risks are much higher than found in Caucasians.

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Year:  1978        PMID: 280791

Source DB:  PubMed          Journal:  N Z Med J        ISSN: 0028-8446


  19 in total

1.  Familial isolated clubfoot is associated with recurrent chromosome 17q23.1q23.2 microduplications containing TBX4.

Authors:  David M Alvarado; Hyuliya Aferol; Kevin McCall; Jason B Huang; Matthew Techy; Jillian Buchan; Janet Cady; Patrick R Gonzales; Matthew B Dobbs; Christina A Gurnett
Journal:  Am J Hum Genet       Date:  2010-07-09       Impact factor: 11.025

2.  Variants in genes that encode muscle contractile proteins influence risk for isolated clubfoot.

Authors:  Katelyn S Weymouth; Susan H Blanton; Michael J Bamshad; Anita E Beck; Christine Alvarez; Steve Richards; Christina A Gurnett; Matthew B Dobbs; Douglas Barnes; Laura E Mitchell; Jacqueline T Hecht
Journal:  Am J Med Genet A       Date:  2011-08-10       Impact factor: 2.802

Review 3.  Update on clubfoot: etiology and treatment.

Authors:  Matthew B Dobbs; Christina A Gurnett
Journal:  Clin Orthop Relat Res       Date:  2009-02-18       Impact factor: 4.176

4.  Resource utilization in clubfoot management.

Authors:  Matthew A Halanski; Jen-Chen Huang; Stewart J Walsh; Haemish A Crawford
Journal:  Clin Orthop Relat Res       Date:  2009-01-27       Impact factor: 4.176

5.  Asymmetric lower-limb malformations in individuals with homeobox PITX1 gene mutation.

Authors:  Christina A Gurnett; Farhang Alaee; Lisa M Kruse; David M Desruisseau; Jacqueline T Hecht; Carol A Wise; Anne M Bowcock; Matthew B Dobbs
Journal:  Am J Hum Genet       Date:  2008-10-23       Impact factor: 11.025

Review 6.  Genetics of clubfoot.

Authors:  Matthew B Dobbs; Christina A Gurnett
Journal:  J Pediatr Orthop B       Date:  2012-01       Impact factor: 1.041

7.  Separating the chicken from the egg: an attempt to discern between clubfoot recurrences and incomplete corrections.

Authors:  Matthew A Halanski; Dayle L Maples; Jan E Davison; Jen-Chen Huang; Haemish A Crawford
Journal:  Iowa Orthop J       Date:  2010

8.  Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot.

Authors:  William Shyy; Kai Wang; Val C Sheffield; Jose A Morcuende
Journal:  J Pediatr Orthop       Date:  2010 Apr-May       Impact factor: 2.324

9.  Functional Assessment of Clubfoot Associated HOXA9, TPM1, and TPM2 Variants Suggests a Potential Gene Regulation Mechanism.

Authors:  Katelyn S Weymouth; Susan H Blanton; Tamar Powell; Chandrashekhar V Patel; Stuart A Savill; Jacqueline T Hecht
Journal:  Clin Orthop Relat Res       Date:  2016-03-28       Impact factor: 4.176

10.  Observations on the epidemiology of club foot in Polynesian and Caucasian populations.

Authors:  I Cartlidge
Journal:  J Med Genet       Date:  1984-08       Impact factor: 6.318

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