Literature DB >> 10978200

Structure-activity relationship of polyisoprenyl benzophenones from Garcinia pyrifera on the tubulin/microtubule system.

D Roux1, H A Hadi, S Thoret, D Guénard, O Thoison, M Païs, T Sévenet.   

Abstract

Microtubule disassembly inhibitory properties have been established for the known polyisoprenylated benzophenones xanthochymol (1a) and guttiferone E (1b). The compounds were isolated from the fruits of Garcinia pyrifera collected in Malaysia. A structure-activity relationship study, including natural and semisynthetic derivatives, delineated some structural features necessary for the interaction with tubulin within this compound class.

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Year:  2000        PMID： 10978200     DOI： 10.1021/np0000872

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  Guttiferones K and L, antiproliferative compounds of Rheedia calcicola from the Madagascar rain forest.

Authors:  Shugeng Cao; Peggy J Brodie; James S Miller; Fidy Ratovoson; Chris Birkinshaw; Sennen Randrianasolo; Etienne Rakotobe; Vincent E Rasamison; David G I Kingston
Journal:  J Nat Prod       Date:  2007-03-10       Impact factor: 4.050

Review 2.  Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets.

Authors:  Armelle T Mbaveng; Victor Kuete; Thomas Efferth
Journal:  Front Pharmacol       Date:  2017-06-02       Impact factor: 5.810

3.  Garcinia xanthochymus Benzophenones Promote Hyphal Apoptosis and Potentiate Activity of Fluconazole against Candida albicans Biofilms.

Authors:  Desmond N Jackson; Lin Yang; ShiBiao Wu; Edward J Kennelly; Peter N Lipke
Journal:  Antimicrob Agents Chemother       Date:  2015-07-20       Impact factor: 5.191

4.  Fragmentation pathways of polycyclic polyisoprenylated benzophenones and degradation profile of nemorosone by multiple-stage tandem mass spectrometry.

Authors:  Anna Lisa Piccinelli; Luca Campone; Fabrizio Dal Piaz; Osmany Cuesta-Rubio; Luca Rastrelli
Journal:  J Am Soc Mass Spectrom       Date:  2009-05-20       Impact factor: 3.109

Review 5.  Use of the in vivo hollow fiber assay in natural products anticancer drug discovery.

Authors:  Qiuwen Mi; John M Pezzuto; Norman R Farnsworth; Mansukh C Wani; A Douglas Kinghorn; Steven M Swanson
Journal:  J Nat Prod       Date:  2009-03-27       Impact factor: 4.050

6.  Targeting MHC Regulation Using Polycyclic Polyprenylated Acylphloroglucinols Isolated from Garcinia bancana.

Authors:  Chloé Coste; Nathalie Gérard; Chau Phi Dinh; Antoine Bruguière; Caroline Rouger; Sow Tein Leong; Khalijah Awang; Pascal Richomme; Séverine Derbré; Béatrice Charreau
Journal:  Biomolecules       Date:  2020-09-02

Review 7.  Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs.

Authors:  Subhash Padhye; Aamir Ahmad; Nikhil Oswal; Fazlul H Sarkar
Journal:  J Hematol Oncol       Date:  2009-09-02       Impact factor: 17.388
  7 in total

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