Literature DB >> 10975457

Protein splicing and its applications.

F B Perler1, E Adam.   

Abstract

Protein splicing elements, termed inteins, provide a fertile source for innovative biotechnology tools. First harnessed for protein purification, inteins are now used to express cytotoxic proteins, to segmentally modify or label proteins, to cyclize proteins or peptides, to study structure-activity relationships and to generate reactive polypeptide termini in expressed proteins for an expanding list of chemoselective reactions, including protein ligation.

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Year:  2000        PMID： 10975457     DOI： 10.1016/s0958-1669(00)00113-0

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  16 in total

1.  InBase: the Intein Database.

Authors:  Francine B Perler
Journal:  Nucleic Acids Res       Date:  2002-01-01       Impact factor: 16.971

2.  Modulation of intein activity by its neighboring extein substrates.

Authors:  Gil Amitai; Brian P Callahan; Matt J Stanger; Georges Belfort; Marlene Belfort
Journal:  Proc Natl Acad Sci U S A       Date:  2009-06-17       Impact factor: 11.205

Review 3.  Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery.

Authors:  Andrew Gould; Yanbin Ji; Teshome L Aboye; Julio A Camarero
Journal:  Curr Pharm Des       Date:  2011-12       Impact factor: 3.116

Review 4.  Biological activities of natural and engineered cyclotides, a novel molecular scaffold for peptide-based therapeutics.

Authors:  Angie E Garcia; Julio A Camarero
Journal:  Curr Mol Pharmacol       Date:  2010-11       Impact factor: 3.339

5.  Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway.

Authors:  Antoine Tinel; Sophie Janssens; Saskia Lippens; Solange Cuenin; Emmanuelle Logette; Bastienne Jaccard; Manfredo Quadroni; Jürg Tschopp
Journal:  EMBO J       Date:  2006-12-07       Impact factor: 11.598

6.  Structure of an engineered intein reveals thiazoline ring and provides mechanistic insight.

Authors:  C Seth Pearson; Reza Nemati; Binbin Liu; Jing Zhang; Matteo Scalabrin; Zhong Li; Hongmin Li; Dan Fabris; Marlene Belfort; Georges Belfort
Journal:  Biotechnol Bioeng       Date:  2019-01-08       Impact factor: 4.530

7.  Distribution of split DnaE inteins in cyanobacteria.

Authors:  Jonathan Caspi; Gil Amitai; Olga Belenkiy; Shmuel Pietrokovski
Journal:  Mol Microbiol       Date:  2003-12       Impact factor: 3.501

8.  Expression of human cationic trypsinogen with an authentic N terminus using intein-mediated splicing in aminopeptidase P deficient Escherichia coli.

Authors:  Orsolya Király; Lan Guan; Edit Szepessy; Miklós Tóth; Zoltán Kukor; Miklós Sahin-Tóth
Journal:  Protein Expr Purif       Date:  2006-02-21       Impact factor: 1.650

9.  Selection and structure of hyperactive inteins: peripheral changes relayed to the catalytic center.

Authors:  Kaori Hiraga; Ikko Soga; John T Dansereau; Brian Pereira; Victoria Derbyshire; Zhenming Du; Chunyu Wang; Patrick Van Roey; Georges Belfort; Marlene Belfort
Journal:  J Mol Biol       Date:  2009-09-08       Impact factor: 5.469

Review 10.  Toxins from cone snails: properties, applications and biotechnological production.

Authors:  Stefan Becker; Heinrich Terlau
Journal:  Appl Microbiol Biotechnol       Date:  2008-03-14       Impact factor: 4.813
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