Literature DB >> 10975450

Homology-independent protein engineering.

S Lutz1, S J Benkovic.   

Abstract

Is structure, rather than sequence, the key to the successful generation of truly novel proteins? While protein evolution by homologous recombination has become an established tool to explore confined regions in sequence space, the generation of functional hybrid proteins by homology-independent methods further expands the scope of protein engineering.

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Year:  2000        PMID： 10975450     DOI： 10.1016/s0958-1669(00)00106-3

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  6 in total

1.  Enhanced crossover SCRATCHY: construction and high-throughput screening of a combinatorial library containing multiple non-homologous crossovers.

Authors:  Yasuaki Kawarasaki; Karl E Griswold; James D Stevenson; Tzvia Selzer; Stephen J Benkovic; Brent L Iverson; George Georgiou
Journal:  Nucleic Acids Res       Date:  2003-11-01       Impact factor: 16.971

2.  Evolvability is a selectable trait.

Authors:  David J Earl; Michael W Deem
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-02       Impact factor: 11.205

3.  Modulation of base-specific mutation and recombination rates enables functional adaptation within the context of the genetic code.

Authors:  Taison Tan; Leonard D Bogarad; Michael W Deem
Journal:  J Mol Evol       Date:  2004-09       Impact factor: 2.395

4.  Structural and functional modularity of proteins in the de novo purine biosynthetic pathway.

Authors:  Hui Li; Walter Fast; Stephen J Benkovic
Journal:  Protein Sci       Date:  2009-05       Impact factor: 6.725

Review 5.  Synthetic biology of modular proteins.

Authors:  Veerle E T Maervoet; Yves Briers
Journal:  Bioengineered       Date:  2016-09-20       Impact factor: 3.269

6.  Quasispecies theory for horizontal gene transfer and recombination.

Authors:  Enrique Muñoz; Jeong-Man Park; Michael W Deem
Journal:  Phys Rev E Stat Nonlin Soft Matter Phys       Date:  2008-12-23
  6 in total

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