Literature DB >> 10975241

Simultaneous determination of mecamylamine, nicotine, and cotinine in plasma by gas chromatography-mass spectrometry.

P Jacob1, S Wu, L Yu, N L Benowitz.   

Abstract

The nicotine receptor antagonist mecamylamine has been shown to increase the efficacy of transdermal nicotine as a pharmacotherapy for tobacco addiction. A product for simultaneous transdermal administration of nicotine and mecamylamine is undergoing clinical trials. In order to carry out pharmacokinetic studies, quantitation of low nanogram per milliliter levels of mecamylamine and nicotine was required. This paper describes a method for simultaneous determination of mecamylamine, nicotine, and the nicotine metabolite, cotinine, in human plasma using gas chromatography-mass spectrometry (GC-MS). Limits of quantitation for mecamylamine, nicotine and cotinine are 2, 1 and 2 ng/ml, respectively.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10975241     DOI： 10.1016/s0731-7085(00)00343-5

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  16 in total

1.  The effect of flavoured and non-flavoured tobacco on subjective experience, topography and toxicant exposure among waterpipe smokers.

Authors:  Ziyad Ben Taleb; Mayra Vargas; Mohammad Ebrahimi Kalan; Alison Breland; Thomas Eissenberg; David Brown; Wasim Maziak
Journal:  Tob Control       Date:  2019-11-25       Impact factor: 7.552

2.  In vivo versus in vitro airway surface liquid nicotine levels following cigarette smoke exposure.

Authors:  Lucy A Clunes; Arlene Bridges; Neil Alexis; Robert Tarran
Journal:  J Anal Toxicol       Date:  2008-04       Impact factor: 3.367

Review 3.  Biomarkers of exposure to new and emerging tobacco delivery products.

Authors:  Suzaynn F Schick; Benjamin C Blount; Peyton Jacob; Najat A Saliba; John T Bernert; Ahmad El Hellani; Peter Jatlow; R Steven Pappas; Lanqing Wang; Jonathan Foulds; Arunava Ghosh; Stephen S Hecht; John C Gomez; Jessica R Martin; Clementina Mesaros; Sanjay Srivastava; Gideon St Helen; Robert Tarran; Pawel K Lorkiewicz; Ian A Blair; Heather L Kimmel; Claire M Doerschuk; Neal L Benowitz; Aruni Bhatnagar
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2017-05-18       Impact factor: 5.464

4.  The effects of smoked nicotine on measures of subjective states and hypothalamic-pituitary-adrenal axis hormones in women during the follicular and luteal phases of the menstrual cycle.

Authors:  Nathalie V Goletiani; Arthur J Siegel; Scott E Lukas; James I Hudson
Journal:  J Addict Med       Date:  2015 May-Jun       Impact factor: 3.702

5.  Simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine, norcotinine and mecamylamine in human urine by liquid chromatography-tandem mass spectrometry.

Authors:  Karl B Scheidweiler; Diaa M Shakleya; Marilyn A Huestis
Journal:  Clin Chim Acta       Date:  2012-02-27       Impact factor: 3.786

6.  Levels of nicotine in dust from homes of smokeless tobacco users.

Authors:  Todd P Whitehead; Catherine Metayer; June-Soo Park; Monique Does; Patricia A Buffler; Stephen M Rappaport
Journal:  Nicotine Tob Res       Date:  2013-07-24       Impact factor: 4.244

7.  Effect of flavour manipulation on low and high-frequency waterpipe users' puff topography, toxicant exposures and subjective experiences.

Authors:  Wasim Maziak; Ziyad Ben Taleb; Mohammad Ebrahimi Kalan; Melissa Ward-Peterson; Zoran Bursac; Olatokunbo Osibogun; Thomas Eissenberg
Journal:  Tob Control       Date:  2019-07-20       Impact factor: 7.552

8.  Flavored Versus Nonflavored Waterpipe Tobacco: A Comparison of Toxicant Exposure, Puff Topography, Subjective Experiences, and Harm Perceptions.

Authors:  Ziyad Ben Taleb; Alison Breland; Raed Bahelah; Mohammad Ebrahimi Kalan; Mayra Vargas-Rivera; Rana Jaber; Thomas Eissenberg; Wasim Maziak
Journal:  Nicotine Tob Res       Date:  2019-08-19       Impact factor: 4.244

9.  Tobacco alkaloids and tobacco-specific nitrosamines in dust from homes of smokeless tobacco users, active smokers, and nontobacco users.

Authors:  Todd P Whitehead; Christopher Havel; Catherine Metayer; Neal L Benowitz; Peyton Jacob
Journal:  Chem Res Toxicol       Date:  2015-04-02       Impact factor: 3.739

10.  Simultaneous and sensitive measurement of nicotine, cotinine, trans-3'-hydroxycotinine and norcotinine in human plasma by liquid chromatography-tandem mass spectrometry.

Authors:  Diaa M Shakleya; Marilyn A Huestis
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2009-08-28       Impact factor: 3.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.