Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Conserved noncoding sequences are reliable guides to regulatory elements.

Literature DB >> 10973062

Conserved noncoding sequences are reliable guides to regulatory elements.

Abstract

A 'working draft' of the human genome sequence is now available. Comparisons with the sequences of mouse and other species will be a powerful approach to identifying functional segments of the noncoding regions, such as gene regulatory elements. However, the choice of a species for most effective comparison differs among various loci.

Entities: Species

Mesh：

Substances：
Interleukins

Year: 2000 PMID： 10973062 DOI： 10.1016/s0168-9525(00)02081-3

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

Keyword Cloud
Cited

157 in total

1. New views of evolution and regulation of vertebrate beta-like globin gene clusters from an orphaned gene in marsupials.

Authors: R C Hardison
Journal: Proc Natl Acad Sci U S A Date: 2001-02-13 Impact factor: 11.205

2. Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.

Authors: Udaya DeSilva; Laura Elnitski; Jacquelyn R Idol; Johannah L Doyle; Weiniu Gan; James W Thomas; Scott Schwartz; Nicole L Dietrich; Stephen M Beckstrom-Sternberg; Jennifer C McDowell; Robert W Blakesley; Gerard G Bouffard; Pamela J Thomas; Jeffrey W Touchman; Webb Miller; Eric D Green
Journal: Genome Res Date: 2002-01 Impact factor: 9.043

3. Deciphering genetic regulatory codes: a challenge for functional genomics.

Authors: Alan M Michelson
Journal: Proc Natl Acad Sci U S A Date: 2002-01-22 Impact factor: 11.205

4. Analysis of similarity within 142 pairs of orthologous intergenic regions of Caenorhabditis elegans and Caenorhabditis briggsae.

Authors: Colleen T Webb; Svetlana A Shabalina; Aleksey Yu Ogurtsov; Alexey S Kondrashov
Journal: Nucleic Acids Res Date: 2002-03-01 Impact factor: 16.971

Conserved noncoding sequences are reliable guides to regulatory elements.

1. New views of evolution and regulation of vertebrate beta-like globin gene clusters from an orphaned gene in marsupials.

2. Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.

3. Deciphering genetic regulatory codes: a challenge for functional genomics.

4. Analysis of similarity within 142 pairs of orthologous intergenic regions of Caenorhabditis elegans and Caenorhabditis briggsae.

5. Genome-wide identification of tissue-specific enhancers in the Ciona tadpole.

6. rVista for comparative sequence-based discovery of functional transcription factor binding sites.

7. GALA, a database for genomic sequence alignments and annotations.

8. Evolutionary conservation of regulatory elements in vertebrate Hox gene clusters.

9. Identification and characterization of multi-species conserved sequences.

10. Reconstructing large regions of an ancestral mammalian genome in silico.