Literature DB >> 10970221

Microbiology. A weak link in TB bacterium is found.

L Helmuth.   

Abstract

The secret of the success of Mycobacterium tuberculosis, the pathogen that causes tuberculosis, is that it can linger undetected in the lungs for decades, hiding from the immune system's macrophages that aim to chew it up and spit it out. Now a team of researchers has uncovered a vulnerability in this resilient bug that suggests new ways to starve it out of its bolt-hole.

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Year:  2000        PMID： 10970221     DOI： 10.1126/science.289.5482.1123a

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  3 in total

1.  Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of isocitrate dehydrogenase 2 (Rv0066c) from Mycobacterium tuberculosis.

Authors:  Georgios N Hatzopoulos; Georgia Kefala; Jochen Mueller-Dieckmann
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-11-28

2.  Mycobacterium tuberculosis (Mtb) isocitrate dehydrogenases show strong B cell response and distinguish vaccinated controls from TB patients.

Authors:  Sharmistha Banerjee; Ashok Nandyala; Raviprasad Podili; V M Katoch; K J R Murthy; Seyed E Hasnain
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-16       Impact factor: 11.205

3.  Novel targeting of PEGylated liposomes for codelivery of TGF-β1 siRNA and four antitubercular drugs to human macrophages for the treatment of mycobacterial infection: a quantitative proteomic study.

Authors:  Ning-Kui Niu; Juan-Juan Yin; Yin-Xue Yang; Zi-Li Wang; Zhi-Wei Zhou; Zhi-Xu He; Xiao-Wu Chen; Xueji Zhang; Wei Duan; Tianxin Yang; Shu-Feng Zhou
Journal:  Drug Des Devel Ther       Date:  2015-08-07       Impact factor: 4.162
  3 in total

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