Literature DB >> 10965248

Connective tissue growth factor in retrocorneal membranes and corneal scars.

K Wunderlich1, B C Senn, P Reiser, M Pech, J Flammer, P Meyer.   

Abstract

We studied the localization and distribution of connective tissue growth factor (CTGF) in corneal scar tissue and membranes using in situ hybridization in 8 corneas from keratoplasty and 4 normal corneas. Identification of the cells was done with immunohistochemistry for SM-alpha-actin, vimentin, and Lu5. CTGF mRNA was found in activated corneal fibroblasts in 7 of 8 scars, 7 of 8 retrocorneal membranes and 2 subepithelial membranes, whereas the control corneas showed no CTGF mRNA expression. Vimentin was positive in all scars, retrocorneal and subepithelial membranes, SM-alpha-actin in 7 of 8 scars and 6 of 8 retrocorneal membranes. These results suggest that CTGF plays a crucial role in corneal wound healing and membrane formation. Copyright 2000 S. Karger AG, Basel

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Year:  2000        PMID： 10965248     DOI： 10.1159/000027517

Source DB:  PubMed          Journal:  Ophthalmologica        ISSN： 0030-3755            Impact factor:   3.250


  14 in total

1.  Development of retrocorneal membrane following pig-to-monkey penetrating keratoplasty.

Authors:  Whayoung Lee; Alex Mammen; Deepinder K Dhaliwal; Cassandra Long; Yuko Miyagawa; David Ayares; David K C Cooper; Hidetaka Hara
Journal:  Xenotransplantation       Date:  2016-11-05       Impact factor: 3.907

2.  Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome.

Authors:  S L Ho; G F Dogar; J Wang; J Crean; Q D Wu; N Oliver; S Weitz; A Murray; P E Cleary; C O'Brien
Journal:  Br J Ophthalmol       Date:  2005-02       Impact factor: 4.638

3.  Expression of insulin-like growth factor 2 receptor in corneal keratocytes during differentiation and in response to wound healing.

Authors:  Richard N Bohnsack; Debra J Warejcka; Lingyan Wang; Stephanie R Gillespie; Audrey M Bernstein; Sally S Twining; Nancy M Dahms
Journal:  Invest Ophthalmol Vis Sci       Date:  2014-10-30       Impact factor: 4.799

4.  A connective tissue growth factor signaling receptor in corneal fibroblasts.

Authors:  Timothy D Blalock; Daniel J Gibson; Matthew R Duncan; Sonal S Tuli; Gary R Grotendorst; Gregory S Schultz
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-06-05       Impact factor: 4.799

Review 5.  Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis.

Authors:  Andrew Leask; Alan Holmes; David J Abraham
Journal:  Curr Rheumatol Rep       Date:  2002-04       Impact factor: 4.592

6.  MicroRNA signature in wound healing following excimer laser ablation: role of miR-133b on TGFβ1, CTGF, SMA, and COL1A1 expression levels in rabbit corneal fibroblasts.

Authors:  Paulette M Robinson; Tsai-Der Chuang; Sriniwas Sriram; Liya Pi; Xiao Ping Luo; Bryon E Petersen; Gregory S Schultz
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-10-23       Impact factor: 4.799

Review 7.  Fibroblast Growth Factor 2 as an Antifibrotic: Antagonism of Myofibroblast Differentiation and Suppression of Pro-Fibrotic Gene Expression.

Authors:  David M Dolivo; Sara A Larson; Tanja Dominko
Journal:  Cytokine Growth Factor Rev       Date:  2017-09-23       Impact factor: 7.638

8.  Effect of connective tissue growth factor on protein kinase expression and activity in human corneal fibroblasts.

Authors:  Siva S Radhakrishnan; Timothy D Blalock; Paulette M Robinson; Genevieve Secker; Julie Daniels; Gary R Grotendorst; Gregory S Schultz
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-12-13       Impact factor: 4.799

9.  Connective tissue growth factor in tear film of the horse: detection, identification and origin.

Authors:  F J Ollivier; D E Brooks; G S Schultz; T D Blalock; S E Andrew; A M Komaromy; T J Cutler; M E Lassaline; M E Kallberg; G B Van Setten
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2003-11-28       Impact factor: 3.117

10.  Gene expression profiling of connective tissue growth factor (CTGF) stimulated primary human tenon fibroblasts reveals an inflammatory and wound healing response in vitro.

Authors:  Axel Seher; Joachim Nickel; Thomas D Mueller; Susanne Kneitz; Susanne Gebhardt; Tobias Meyer ter Vehn; Guenther Schlunck; Walter Sebald
Journal:  Mol Vis       Date:  2011-01-08       Impact factor: 2.367
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