| Literature DB >> 10962553 |
S E Scanga1, L Ruel, R C Binari, B Snow, V Stambolic, D Bouchard, M Peters, B Calvieri, T W Mak, J R Woodgett, A S Manoukian.
Abstract
Akt (or PKB) is an oncogene involved in the regulation of cell survival. Akt is regulated by phosphatidylinositol 3-OH kinase (PI3'K) signaling and has shown to be hyperactivated through the loss of the PTEN tumor suppressor. In Drosophila, insulin signaling as studied using the Drosophila IRS-4 homolog (Chico) has been shown to be a crucial regulator of cell size. We have studied Drosophila Akt (Dakt1) and have shown that it is also involved in the regulation of cell size. Furthermore we have performed genetic epistasis tests to demonstrate that in Drosophila, PI3'K, PTEN and Akt comprise a signaling cassette that is utilized during multiple stages of development. In addition, we show that this signaling cassette is also involved in the regulation of cell survival during embryogenesis. This study therefore establishes the evolutionary conservation of this signaling pathway in Drosophila. Oncogene (2000) 19, 3971 - 3977.Entities:
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Year: 2000 PMID： 10962553 DOI： 10.1038/sj.onc.1203739
Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867