Infection-resistant nonleachable materials for urologic devices.

Bacterial colonization is the primary clinical problem faced by the surgeon and medical device innovator. Despite the absence of effective systemic treatment, medical implants and devices have been deployed with increasing success over the past five decades. Infection-resistant materials (IRMs) are a relatively recent addition to the science of implant and device development. The first IRM utilized leachable antimicrobial agents. Nonleachable technologies are being developed, some of which have the potential to make organ replacement even more successful in the future.