S Gravius1, D C Wirtz2. 1. Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Deutschland. sascha.gravius@ukb.uni-bonn.de. 2. Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Deutschland.
Abstract
BACKGROUND: Antimicrobial coatings have a great potential in the treatment and prevention of periprosthetic joint infection. OBJECTIVE: To present established and novel concepts of antimicrobial coatings. METHODS: A literature review and discussion of published concepts in basic research, pre-clinical animal studies, and clinical practice were carried out. RESULTS: To date there has been a wide range of technical solutions (anti-adhesive surfaces, bioactive surfaces with antimicrobial effects, surfaces releasing antimicrobial substances, nanostructures, bioactive surfaces affecting biofilm development) demonstrating a high potential in pre-clinical studies. Only a few with the bactericidal activity of silver ions have been prepared for the market. Conclusive results with regard to biocompatibility and toxicity are lacking. DISCUSSION: Despite the great potential of antimicrobial coatings, no conclusive decisions can be made because of the limited data and the lack of evidence of their clinical efficacy on the basis of prospective controlled clinical studies. In addition to their unlimited biocompatibility, innovative concepts have to be feasible in everyday clinical routine.
BACKGROUND: Antimicrobial coatings have a great potential in the treatment and prevention of periprosthetic joint infection. OBJECTIVE: To present established and novel concepts of antimicrobial coatings. METHODS: A literature review and discussion of published concepts in basic research, pre-clinical animal studies, and clinical practice were carried out. RESULTS: To date there has been a wide range of technical solutions (anti-adhesive surfaces, bioactive surfaces with antimicrobial effects, surfaces releasing antimicrobial substances, nanostructures, bioactive surfaces affecting biofilm development) demonstrating a high potential in pre-clinical studies. Only a few with the bactericidal activity of silver ions have been prepared for the market. Conclusive results with regard to biocompatibility and toxicity are lacking. DISCUSSION: Despite the great potential of antimicrobial coatings, no conclusive decisions can be made because of the limited data and the lack of evidence of their clinical efficacy on the basis of prospective controlled clinical studies. In addition to their unlimited biocompatibility, innovative concepts have to be feasible in everyday clinical routine.
Authors: H van de Belt; D Neut; D R Uges; W Schenk; J R van Horn; H C van der Mei; H J Busscher Journal: Biomaterials Date: 2000-10 Impact factor: 12.479
Authors: Carla Renata Arciola; Davide Campoccia; Pietro Speziale; Lucio Montanaro; John William Costerton Journal: Biomaterials Date: 2012-06-12 Impact factor: 12.479
Authors: Matthias D Wimmer; Patrick Vavken; Geert I Pagenstert; Victor Valderrabano; Thomas M Randau; Dieter C Wirtz; Sascha Gravius Journal: J Infect Date: 2013-02-13 Impact factor: 6.072
Authors: Suzanne Stewart; Stephanie Barr; Julie Engiles; Noreen J Hickok; Irving M Shapiro; Dean W Richardson; Javad Parvizi; Thomas P Schaer Journal: J Bone Joint Surg Am Date: 2012-08-01 Impact factor: 5.284