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Literature DB >> 109570

Ef2: a new LY-3-linked light-chain marker expressed in normal mouse serum immunoglobulin.

Abstract

A new light-chain marker has been detected in normal mouse serum immunoglobulin light chains by gel isoelectric focusing. The marker (Ef2) involves the presence of two major and several minor bands in the normal light-chain IF profiles. Strains expressing the marker IF bands are designated Igk-Ef2a, whereas those lacking the bands are Igk-Ef2b. The majority of inbred strains are Igk-Ef2a. Strains found to be Igk-Ef2b are NZB/BlNJ, BDP/J, C58/J, I/LnJ, CE/J, and P/J. The strain distribution of the alleles differs from the distribution of alleles at the Ly-2 and Ly-3 loci, suggesting the new marker may represent a separate locus. Genetic studies have shown that Igk-Ef2 locus is closely linked to Igk-Ef1 and Hd loci on Chromosome 6, indicating that it is also closely linked to Ly-3. The relative importance of the bands controlled by the Igk-Ef2 locus suggests that the entire normal light-chain pool could be controlled by as few as 100 such loci.

Entities: Gene Species

Mesh：

Substances：

Year: 1979 PMID： 109570 PMCID： PMC2184900 DOI： 10.1084/jem.149.6.1477

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

23 in total

1. Evidence for close linkage of a mouse light chain marker with the Ly-2,3 locus.

Authors: D M Gibson; B A Taylor; M Cherry
Journal: J Immunol Date: 1978-10 Impact factor: 5.422

2. A complete immunoglobulin gene is created by somatic recombination.

Authors: C Brack; M Hirama; R Lenhard-Schuller; S Tonegawa
Journal: Cell Date: 1978-09 Impact factor: 41.582

3. Multiplicity of germline genes specifying a group of related mouse kappa chains with implications for the generation of immunoglobulin diversity.

Authors: O Valbuena; K B Marcu; M Weigert; R P Perry
Journal: Nature Date: 1978 Dec 21-28 Impact factor: 49.962

4. Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse.

Authors: H Hengartner; T Meo; E Müller
Journal: Proc Natl Acad Sci U S A Date: 1978-09 Impact factor: 11.205

5. Standardized nomenclature for inbred strains of mice: sixth listing.

Authors: J Staats
Journal: Cancer Res Date: 1976-12 Impact factor: 12.701

6. Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse.

Authors: E A Boyse; M Miyazawa; T Aoki; L J Old
Journal: Proc R Soc Lond B Biol Sci Date: 1968-06-11

7. Immunoglobulin light chain mRNA is processed from large nuclear RNA.

Authors: M Gilmore-Hebert; R Wall
Journal: Proc Natl Acad Sci U S A Date: 1978-01 Impact factor: 11.205

8. The IB-peptide marker and the Ly-3 surface alloantigen: structural studies of a V kappa-region polymorphism and a T-cell marker determined by linked genes.

Authors: P D Gottlieb; P J Durda
Journal: Cold Spring Harb Symp Quant Biol Date: 1977

9. On the genetic dissection of a specific humoral immune response to alpha(1,3) dextran.

Authors: W Geckeler; B Blomberg; C de Preval; M Cohn
Journal: Cold Spring Harb Symp Quant Biol Date: 1977

10. Rearrangement of genetic information may produce immunoglobulin diversity.

Authors: M Weigert; L Gatmaitan; E Loh; J Schilling; L Hood
Journal: Nature Date: 1978 Dec 21-28 Impact factor: 49.962

14 in total

1. Structural differences in a single gene encoding the V kappa Ser group of light chains explain the existence of two mouse light-chain genetic markers.

Authors: R T Boyd; M M Goldrick; P D Gottlieb
Journal: Proc Natl Acad Sci U S A Date: 1986-12 Impact factor: 11.205

2. The organization of immunoglobulin variable kappa chain genes on mouse chromosome 6.

Authors: L A D'Hoostelaere; D M Gibson
Journal: Immunogenetics Date: 1986 Impact factor: 2.846

3. Genetic polymorphism at the mouse immunoglobulin J kappa locus (Igk-J) as demonstrated by Southern hybridization and nucleotide sequence analysis.

Authors: R T Boyd; M M Goldrick; P D Gottlieb
Journal: Immunogenetics Date: 1986 Impact factor: 2.846

4. Recombination between kappa chain genetic markers in the mouse.

Authors: D M Gibson; S J MacLean; D Anctil; B J Mathieson
Journal: Immunogenetics Date: 1984 Impact factor: 2.846

5. Recombination between kappa chain genetic markers and the Lyt-3 locus.

Authors: D M Gibson; S J Maclean; M Cherry
Journal: Immunogenetics Date: 1983 Impact factor: 2.846

6. Genetic polymorphism at the kappa chain locus in mice: comparisons of restriction enzyme hybridization fragments of variable and constant region genes.

Authors: K Huppi; E Jouvin-Marche; C Scott; M Potter; M Weigert
Journal: Immunogenetics Date: 1985 Impact factor: 2.846

10. Expression of an idiotype (Id-460) during in vivo anti-dinitrophenyl antibody responses. I. Mapping of genes for Id-460 expression to the variable region of immunoglobulin heavy-chain locus and to the variable region of immunoglobulin kappa-light-chain locus.

Authors: E A Dzierzak; C A Janeway; R W Rosenstein; P D Gottlieb
Journal: J Exp Med Date: 1980-09-01 Impact factor: 14.307