Literature DB >> 10954574

Coinfection of SCID-hu Thy/Liv mice with human herpesvirus 6 and human immunodeficiency virus type 1.

A Gobbi1, C A Stoddart, G Locatelli, F Santoro, C Bare, V Linquist-Stepps, M E Moreno, N W Abbey, B G Herndier, M S Malnati, J M McCune, P Lusso.   

Abstract

Human herpesvirus 6 (HHV-6) has been proposed as a potential cofactor in the progression of human immunodeficiency virus type 1 (HIV-1) disease. We used the SCID-hu Thy/Liv mouse model to evaluate the in vivo interactions between HHV-6 and HIV-1. Our results demonstrate that HHV-6 and HIV-1 can simultaneously replicate in the human thymus in vivo. In this model, however, the presence of one virus appears not to modify the replication or cytopathicity of the other.

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Year:  2000        PMID： 10954574      PMCID： PMC116384          DOI： 10.1128/jvi.74.18.8726-8731.2000

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  33 in total

1.  Productive dual infection of human CD4+ T lymphocytes by HIV-1 and HHV-6.

Authors:  P Lusso; B Ensoli; P D Markham; D V Ablashi; S Z Salahuddin; E Tschachler; F Wong-Staal; R C Gallo
Journal:  Nature       Date:  1989-01-26       Impact factor: 49.962

2.  Human herpesvirus 6 inhibits human immunodeficiency virus type 1 replication in cell culture.

Authors:  J A Levy; A Landay; E T Lennette
Journal:  J Clin Microbiol       Date:  1990-10       Impact factor: 5.948

3.  Suppression of human immunodeficiency virus type 1 replication by human herpesvirus-6.

Authors:  D R Carrigan; K K Knox; M A Tapper
Journal:  J Infect Dis       Date:  1990-10       Impact factor: 5.226

4.  HIV induces thymus depletion in vivo.

Authors:  M L Bonyhadi; L Rabin; S Salimi; D A Brown; J Kosek; J M McCune; H Kaneshima
Journal:  Nature       Date:  1993-06-24       Impact factor: 49.962

5.  Human cytomegalovirus in a SCID-hu mouse: thymic epithelial cells are prominent targets of viral replication.

Authors:  E S Mocarski; M Bonyhadi; S Salimi; J M McCune; H Kaneshima
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-01       Impact factor: 11.205

6.  Infection of the SCID-hu mouse by HIV-1.

Authors:  R Namikawa; H Kaneshima; M Lieberman; I L Weissman; J M McCune
Journal:  Science       Date:  1988-12-23       Impact factor: 47.728

7.  Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders.

Authors:  S Z Salahuddin; D V Ablashi; P D Markham; S F Josephs; S Sturzenegger; M Kaplan; G Halligan; P Biberfeld; F Wong-Staal; B Kramarsky
Journal:  Science       Date:  1986-10-31       Impact factor: 47.728

8.  Human herpesvirus 6 (HHV-6) causes severe thymocyte depletion in SCID-hu Thy/Liv mice.

Authors:  A Gobbi; C A Stoddart; M S Malnati; G Locatelli; F Santoro; N W Abbey; C Bare; V Linquist-Stepps; M B Moreno; B G Herndier; P Lusso; J M McCune
Journal:  J Exp Med       Date:  1999-06-21       Impact factor: 14.307

9.  Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice.

Authors:  D Dittmer; C Stoddart; R Renne; V Linquist-Stepps; M E Moreno; C Bare; J M McCune; D Ganem
Journal:  J Exp Med       Date:  1999-12-20       Impact factor: 14.307

10.  Long-term human hematopoiesis in the SCID-hu mouse.

Authors:  R Namikawa; K N Weilbaecher; H Kaneshima; E J Yee; J M McCune
Journal:  J Exp Med       Date:  1990-10-01       Impact factor: 14.307
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  6 in total

Review 1.  Update on human herpesvirus 6 biology, clinical features, and therapy.

Authors:  Leen De Bolle; Lieve Naesens; Erik De Clercq
Journal:  Clin Microbiol Rev       Date:  2005-01       Impact factor: 26.132

2.  Real-time quantitative PCR for human herpesvirus 6 DNA.

Authors:  G Locatelli; F Santoro; F Veglia; A Gobbi; P Lusso; M S Malnati
Journal:  J Clin Microbiol       Date:  2000-11       Impact factor: 5.948

Review 3.  Mice with human immune system components as in vivo models for infections with human pathogens.

Authors:  Patrick C Rämer; Obinna Chijioke; Sonja Meixlsperger; Carol S Leung; Christian Münz
Journal:  Immunol Cell Biol       Date:  2011-02-08       Impact factor: 5.126

4.  Pathogenic effects of human herpesvirus 6 in human lymphoid tissue ex vivo.

Authors:  Jean-Charles Grivel; Fabio Santoro; Silvia Chen; Giovanni Fagá; Mauro S Malnati; Yoshinori Ito; Leonid Margolis; Paolo Lusso
Journal:  J Virol       Date:  2003-08       Impact factor: 5.103

Review 5.  The utilization of humanized mouse models for the study of human retroviral infections.

Authors:  Rachel Van Duyne; Caitlin Pedati; Irene Guendel; Lawrence Carpio; Kylene Kehn-Hall; Mohammed Saifuddin; Fatah Kashanchi
Journal:  Retrovirology       Date:  2009-08-12       Impact factor: 4.602

6.  Animal models for human herpesvirus 6 infection.

Authors:  Joséphine M Reynaud; Branka Horvat
Journal:  Front Microbiol       Date:  2013-07-04       Impact factor: 5.640
  6 in total

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