OBJECTIVE: To determine the relation between plasma leptin concentrations and metabolic control in human diabetes mellitus. DESIGN AND SUBJECTS: Cross sectional study consisting of 156 patients with diabetes mellitus type 1 (n=42), type 2 (n=114), and non-diabetic subjects (n=74). RESULTS: Plasma leptin concentrations were lower (P<0.05) in type 1 (8.3+/-1.7 ng/ml) and type 2 diabetic (14.9+/-1.8 ng/ml) than in non-diabetic humans (18.3+/-1.9 ng/ml). Only female type 1 and type 2 diabetic subjects also had decreased leptin/BMI ratios (P<0.05 vs non-diabetic females). The log rank test identified age-adjusted correlation of plasma leptin concentration with sex (P<0.0004) and body mass index (P<0.0218), but not with glycosylated haemoglobin A1c (P>0.5) in all groups. Plasma leptin was correlated with age (P<0.0058) and serum triglycerides (P<0.0199) in type 1 diabetic patients, and with serum cholesterol (P<0.0059) and LDL (P<0.0013) in type 2 diabetic patients. CONCLUSIONS: Defective leptin production and/or secretion might be present independently of metabolic control in female patients with type 1 or type 2 diabetes mellitus.
OBJECTIVE: To determine the relation between plasma leptin concentrations and metabolic control in humandiabetes mellitus. DESIGN AND SUBJECTS: Cross sectional study consisting of 156 patients with diabetes mellitus type 1 (n=42), type 2 (n=114), and non-diabetic subjects (n=74). RESULTS: Plasma leptin concentrations were lower (P<0.05) in type 1 (8.3+/-1.7 ng/ml) and type 2 diabetic (14.9+/-1.8 ng/ml) than in non-diabetichumans (18.3+/-1.9 ng/ml). Only female type 1 and type 2 diabetic subjects also had decreased leptin/BMI ratios (P<0.05 vs non-diabetic females). The log rank test identified age-adjusted correlation of plasma leptin concentration with sex (P<0.0004) and body mass index (P<0.0218), but not with glycosylated haemoglobin A1c (P>0.5) in all groups. Plasma leptin was correlated with age (P<0.0058) and serum triglycerides (P<0.0199) in type 1 diabeticpatients, and with serum cholesterol (P<0.0059) and LDL (P<0.0013) in type 2 diabeticpatients. CONCLUSIONS: Defective leptin production and/or secretion might be present independently of metabolic control in female patients with type 1 or type 2 diabetes mellitus.
Authors: Geun Hyang Kim; Andras Szabo; Emily M King; Jennifer Ayala; Julio E Ayala; Judith Y Altarejos Journal: Mol Metab Date: 2014-12-19 Impact factor: 7.422
Authors: Christopher D Morrison; Marina A DuVall; Cristal M Hill; Redin A Spann; David H McDougal Journal: J Diabetes Complications Date: 2021-07-15 Impact factor: 3.219
Authors: Lana Leung; Jonathan Kang; Esa Rayyan; Ashesh Bhakta; Brennan Barrett; David Larsen; Ryan Jelinek; Justin Willey; Scott Cochran; Tom L Broderick; Layla Al-Nakkash Journal: Diabetes Metab Syndr Obes Date: 2014-07-21 Impact factor: 3.168