Literature DB >> 34325985

Leptin receptor signaling is required for intact hypoglycemic counterregulation: A study in male Zucker rats.

Christopher D Morrison1, Marina A DuVall2, Cristal M Hill1, Redin A Spann1, David H McDougal3.   

Abstract

Hypoglycemia is a major barrier to clinical management of persons with diabetes. Emerging evidence supports a role for leptin in gating hypoglycemic counterregulation. This work demonstrates that male leptin receptor null, Zucker (fa/fa), rats display severe impairments in hypoglycemic counterregulation. Thus, augmenting leptin levels may have clinical utility for preventing hypoglycemia.
Copyright © 2021 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Diabetes; Hypoglycemia; Leptin; Leptin receptors; Zucker rats

Mesh：

Substances：

Year:  2021        PMID： 34325985      PMCID： PMC8435018          DOI： 10.1016/j.jdiacomp.2021.107994

Source DB:  PubMed          Journal:  J Diabetes Complications        ISSN： 1056-8727            Impact factor:   3.219


  20 in total

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Authors:  C Guillaume-Gentil; F Rohner-Jeanrenaud; F Abramo; G E Bestetti; G L Rossi; B Jeanrenaud
Journal:  Endocrinology       Date:  1990-04       Impact factor: 4.736

Review 2.  Metreleptin: first global approval.

Authors:  Ken Chou; Caroline M Perry
Journal:  Drugs       Date:  2013-06       Impact factor: 9.546

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Journal:  Am J Physiol       Date:  1993-02

Review 4.  Leptin signaling in brain: A link between nutrition and cognition?

Authors:  Christopher D Morrison
Journal:  Biochim Biophys Acta       Date:  2008-12-24

5.  Decreased central and peripheral catecholaminergic activation in obese Zucker rats.

Authors:  K Pacak; R McCarty; M Palkovits; G Cizza; I J Kopin; D S Goldstein; G P Chrousos
Journal:  Endocrinology       Date:  1995-10       Impact factor: 4.736

6.  Estrogen blunts neuroendocrine and metabolic responses to hypoglycemia.

Authors:  Darleen A Sandoval; Andrew C Ertl; M Antoinette Richardson; Donna B Tate; Stephen N Davis
Journal:  Diabetes       Date:  2003-07       Impact factor: 9.461

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Authors:  S N Davis; R E Goldstein; J Jacobs; L Price; R Wolfe; A D Cherrington
Journal:  Diabetes       Date:  1993-02       Impact factor: 9.461

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Authors:  J Allars; D A York
Journal:  Int J Obes       Date:  1986

9.  Long-term effectiveness and safety of metreleptin in the treatment of patients with partial lipodystrophy.

Authors:  Elif A Oral; Phillip Gorden; Elaine Cochran; David Araújo-Vilar; David B Savage; Alison Long; Gregory Fine; Taylor Salinardi; Rebecca J Brown
Journal:  Endocrine       Date:  2019-02-25       Impact factor: 3.633

Review 10.  Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetes.

Authors:  Bingxuan Wang; P Charukeshi Chandrasekera; John J Pippin
Journal:  Curr Diabetes Rev       Date:  2014-03
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