Literature DB >> 10950864

The Dlk1 and Gtl2 genes are linked and reciprocally imprinted.

J V Schmidt1, P G Matteson, B K Jones, X J Guan, S M Tilghman.   

Abstract

Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 gene as a new imprinted gene that is paternally expressed. Furthermore, we show that Dlk1 is tightly linked to the maternally expressed Gtl2 gene. Dlk1 and Gtl2 are coexpressed and respond in a reciprocal manner to loss of DNA methylation. These genes are likely to represent a new example of coordinated imprinting of linked genes.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10950864      PMCID： PMC316857     

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  33 in total

1.  Screening for imprinted genes by allelic message display: identification of a paternally expressed gene impact on mouse chromosome 18.

Authors:  Y Hagiwara; M Hirai; K Nishiyama; I Kanazawa; T Ueda; Y Sakaki; T Ito
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-19       Impact factor: 11.205

2.  Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster.

Authors:  T Caspary; M A Cleary; C C Baker; X J Guan; S M Tilghman
Journal:  Mol Cell Biol       Date:  1998-06       Impact factor: 4.272

Review 3.  Competition--a common motif for the imprinting mechanism?

Authors:  D P Barlow
Journal:  EMBO J       Date:  1997-12-01       Impact factor: 11.598

4.  Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs.

Authors:  K A Moore; B Pytowski; L Witte; D Hicklin; I R Lemischka
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-15       Impact factor: 11.205

5.  Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern.

Authors:  R Shemer; Y Birger; A D Riggs; A Razin
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-16       Impact factor: 11.205

6.  Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.

Authors:  K P Brady; L B Rowe; H Her; T J Stevens; J Eppig; D J Sussman; J Sikela; D R Beier
Journal:  Genome Res       Date:  1997-11       Impact factor: 9.043

7.  Imprinted expression of the Igf2r gene depends on an intronic CpG island.

Authors:  A Wutz; O W Smrzka; N Schweifer; K Schellander; E F Wagner; D P Barlow
Journal:  Nature       Date:  1997-10-16       Impact factor: 49.962

8.  Modulated expression of the epidermal growth factor-like homeotic protein dlk influences stromal-cell-pre-B-cell interactions, stromal cell adipogenesis, and pre-B-cell interleukin-7 requirements.

Authors:  S R Bauer; M J Ruiz-Hidalgo; E K Rudikoff; J Goldstein; J Laborda
Journal:  Mol Cell Biol       Date:  1998-09       Impact factor: 4.272

9.  The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA.

Authors:  K Schuster-Gossler; P Bilinski; T Sado; A Ferguson-Smith; A Gossler
Journal:  Dev Dyn       Date:  1998-06       Impact factor: 3.780

10.  Genomic imprinting is disrupted in interspecific Peromyscus hybrids.

Authors:  P B Vrana; X J Guan; R S Ingram; S M Tilghman
Journal:  Nat Genet       Date:  1998-12       Impact factor: 38.330
View more
  112 in total

1.  Roles for genomic imprinting and the zygotic genome in placental development.

Authors:  P Georgiades; M Watkins; G J Burton; A C Ferguson-Smith
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-27       Impact factor: 11.205

2.  Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation.

Authors:  A A Wylie; S K Murphy; T C Orton; R L Jirtle
Journal:  Genome Res       Date:  2000-11       Impact factor: 9.043

3.  Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals.

Authors:  Brad A Freking; Susan K Murphy; Andrew A Wylie; Simon J Rhodes; John W Keele; Kreg A Leymaster; Randy L Jirtle; Timothy P L Smith
Journal:  Genome Res       Date:  2002-10       Impact factor: 9.043

4.  A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain.

Authors:  Hervé Seitz; Hélène Royo; Marie-Line Bortolin; Shau-Ping Lin; Anne C Ferguson-Smith; Jérôme Cavaillé
Journal:  Genome Res       Date:  2004-08-12       Impact factor: 9.043

5.  Restoration of Dlk1 and Rtl1 is necessary but insufficient to rescue lethality in intergenic differentially methylated region (IG-DMR)-deficient mice.

Authors:  Nozomi Takahashi; Ryota Kobayashi; Tomohiro Kono
Journal:  J Biol Chem       Date:  2010-05-28       Impact factor: 5.157

6.  Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene.

Authors:  Yunli Zhou; Pornsuk Cheunsuchon; Yuki Nakayama; Michael W Lawlor; Ying Zhong; Kimberley A Rice; Li Zhang; Xun Zhang; Francesca E Gordon; Hart G W Lidov; Roderick T Bronson; Anne Klibanski
Journal:  Development       Date:  2010-07-07       Impact factor: 6.868

7.  Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progression.

Authors:  Xun Zhang; Roger Gejman; Ali Mahta; Ying Zhong; Kimberley A Rice; Yunli Zhou; Pornsuk Cheunsuchon; David N Louis; Anne Klibanski
Journal:  Cancer Res       Date:  2010-02-23       Impact factor: 12.701

8.  BEGAIN: a novel imprinted gene that generates paternally expressed transcripts in a tissue- and promoter-specific manner in sheep.

Authors:  Maria A Smit; Xavier Tordoir; Gabor Gyapay; Noelle E Cockett; Michel Georges; Carole Charlier
Journal:  Mamm Genome       Date:  2005-10-29       Impact factor: 2.957

9.  Increased plasticity of genomic imprinting of Dlk1 in brain is due to genetic and epigenetic factors.

Authors:  Sylvie Croteau; David Roquis; Marie-Claude Charron; Danielle Frappier; Daniel Yavin; J Conceptión Loredo-Osti; Thomas J Hudson; Anna K Naumova
Journal:  Mamm Genome       Date:  2005-02       Impact factor: 2.957

10.  Overexpression of Pref-1 in pancreatic islet β-cells in mice causes hyperinsulinemia with increased islet mass and insulin secretion.

Authors:  Yuhui Wang; Kichoon Lee; Yang Soo Moon; Maryam Ahmadian; Kee-Hong Kim; Karim Roder; Chulho Kang; Hei Sook Sul
Journal:  Biochem Biophys Res Commun       Date:  2015-04-24       Impact factor: 3.575
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.