Literature DB >> 10947856

Role of CD8 T cells in mycobacterial infections.

S M Smith1, H M Dockrell.   

Abstract

The interaction between IFN-gamma-secreting CD4+ T cells and macrophages has long been established as integral in the protective immune response against tuberculosis. More recently, evidence from murine experiments and human studies has begun to demonstrate an essential role for MHC class I restricted CD8+ T cells in this immune response. CD8+ T cells can produce the protective cytokines IFN-gamma and TNF-alpha in addition to their classical cytolytic functions. However, the exact protective mechanisms and antigens recognized by these important cells remain poorly characterized.

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Year:  2000        PMID： 10947856     DOI： 10.1046/j.1440-1711.2000.00936.x

Source DB:  PubMed          Journal:  Immunol Cell Biol        ISSN： 0818-9641            Impact factor:   5.126


  12 in total

1.  HLA-B*35-restricted CD8(+)-T-cell epitope in Mycobacterium tuberculosis Rv2903c.

Authors:  Michèl R Klein; Abdulrahman S Hammond; Steve M Smith; Assan Jaye; Pauline T Lukey; Keith P W J McAdam
Journal:  Infect Immun       Date:  2002-02       Impact factor: 3.441

2.  Extensive Mycobacterium bovis BCG infection of liver parenchymal cells in immunocompromised mice.

Authors:  J W Mills; L Ryan; R LaCourse; R J North
Journal:  Infect Immun       Date:  2001-05       Impact factor: 3.441

3.  Mice lacking the multidrug resistance protein 1 have a transiently impaired immune response during tuberculosis.

Authors:  A Verbon; J C Leemans; S Weijer; S Florquin; T Van Der Poll
Journal:  Clin Exp Immunol       Date:  2002-10       Impact factor: 4.330

4.  Rhodococcus equi-specific cytotoxic T lymphocytes in immune horses and development in asymptomatic foals.

Authors:  Kristin M Patton; Travis C McGuire; Melissa T Hines; Robert H Mealey; Stephen A Hines
Journal:  Infect Immun       Date:  2005-04       Impact factor: 3.441

5.  Gamma interferon responses of CD4 and CD8 T-cell subsets are quantitatively different and independent of each other during pulmonary Mycobacterium bovis BCG infection.

Authors:  Patricia Ngai; Sarah McCormick; Cherrie Small; Xizhong Zhang; Anna Zganiacz; Naoko Aoki; Zhou Xing
Journal:  Infect Immun       Date:  2007-02-16       Impact factor: 3.441

6.  Investigation of the role of CD8+ T cells in bovine tuberculosis in vivo.

Authors:  B Villarreal-Ramos; M McAulay; V Chance; M Martin; J Morgan; C J Howard
Journal:  Infect Immun       Date:  2003-08       Impact factor: 3.441

7.  Identification of an HLA-A*0201-restricted T-cell epitope on the MPT51 protein, a major secreted protein derived from Mycobacterium tuberculosis, by MPT51 overlapping peptide screening.

Authors:  Taiki Aoshi; Toshi Nagata; Mina Suzuki; Masato Uchijima; Dai Hashimoto; Alireza Rafiei; Takafumi Suda; Kingo Chida; Yukio Koide
Journal:  Infect Immun       Date:  2008-01-22       Impact factor: 3.441

8.  Cytolytic CD8+ T cells recognizing CFP10 are recruited to the lung after Mycobacterium tuberculosis infection.

Authors:  Arati B Kamath; Joshua Woodworth; Xiaowei Xiong; Chad Taylor; Yu Weng; Samuel M Behar
Journal:  J Exp Med       Date:  2004-11-22       Impact factor: 14.307

Review 9.  Recent advances in our understanding of human host responses to tuberculosis.

Authors:  N W Schluger
Journal:  Respir Res       Date:  2001-03-29

10.  The beneficial effects of adjunctive recombinant human interleukin-2 for multidrug resistant tuberculosis.

Authors:  Hong Shen; Rui Min; Qi Tan; Weiping Xie; Hong Wang; Hongqiu Pan; Li Zhang; Hongtao Xu; Xia Zhang; Jianzhong Dai
Journal:  Arch Med Sci       Date:  2015-06-19       Impact factor: 3.318
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