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Literature DB >> 1094455

Novel mutants of Escherichia coli that accumulate very small DNA replicative intermediates.

Abstract

A new group of mutants has been isolated which, during short pulses, incorporate (3-H)thymidine into DNA fragments that are substantially smaller than Okazaki fragments. These small fragments can be chased into DNA of high-molecular-weight, and thus may be precursors in DNA replication, During longer pulses, label also appears in DNA of higher molecular weight, although at an abnormally slow rate. The mutations map at a previously undescribed locus (dnaS) at 72 min on the E. coli chromosome.

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Year: 1975 PMID： 1094455 PMCID： PMC432714 DOI： 10.1073/pnas.72.6.2150

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

19 in total

Review 1. Escherichia coli K-12 F-prime factors, old and new.

Authors: K B Low
Journal: Bacteriol Rev Date: 1972-12

Review 2. Linkage map of Escherichia coli strain K-12.

Authors: A L Taylor; C D Trotter
Journal: Bacteriol Rev Date: 1972-12

3. Thymine-labelled deoxyoligonucleotide involved in DNA chain growth in Bacillus subtilis.

Authors: H F Wang; R Sternglanz
Journal: Nature Date: 1974-03-08 Impact factor: 49.962

4. A mutant of Escherichia coli K12 deficient in the 5'-3' exonucleolytic activity of DNA polymerase I. I. General characterization.

Authors: B W Glickman; C A van Sluis; H L Heijneker; A Rörsch
Journal: Mol Gen Genet Date: 1973-07-31

5. Genetic and enzymatic characterization of a conditional lethal mutant of Escherichia coli K12 with a temperature-sensitive DNA ligase.

Authors: E B Konrad; P Modrich; I R Lehman
Journal: J Mol Biol Date: 1973-07-15 Impact factor: 5.469

6. DNA synthesis in nucleotide-permeable Escherichia coli cells. VII. Conversion of phi chi-174 DNA to its replicative form.

Authors: U Hess; H Dürwald; H Hoffmann- Berling
Journal: J Mol Biol Date: 1973-02-05 Impact factor: 5.469

5. Repair of cross-linked DNA and survival of Escherichia coli treated with psoralen and light: effects of mutations influencing genetic recombination and DNA metabolism.

Authors: R R Sinden; R S Cole
Journal: J Bacteriol Date: 1978-11 Impact factor: 3.490

10. Recombinant levels of Escherichia coli K-12 mutants deficient in various replication, recombination, or repair genes.

Authors: J Zieg; V F Maples; S R Kushner
Journal: J Bacteriol Date: 1978-06 Impact factor: 3.490

Novel mutants of Escherichia coli that accumulate very small DNA replicative intermediates.

Review 1. Escherichia coli K-12 F-prime factors, old and new.

Review 2. Linkage map of Escherichia coli strain K-12.

3. Thymine-labelled deoxyoligonucleotide involved in DNA chain growth in Bacillus subtilis.

4. A mutant of Escherichia coli K12 deficient in the 5'-3' exonucleolytic activity of DNA polymerase I. I. General characterization.

5. Genetic and enzymatic characterization of a conditional lethal mutant of Escherichia coli K12 with a temperature-sensitive DNA ligase.

6. DNA synthesis in nucleotide-permeable Escherichia coli cells. VII. Conversion of phi chi-174 DNA to its replicative form.

7. Intermediate in SV40 DNA chain growth.

8. Genetics and function of DNA ligase in Escherichia coli.

9. Slow joining of newly replicated DNA chains in DNA polymerase I-deficient Escherichia coli mutants.

10. RNA-linked short DNA fragments during polyoma replication.

1. Escherichia coli mutants deficient in deoxyuridine triphosphatase.

2. Novel structure at 5'-ends of nascent DNA chains.

3. DNA intermediates at the Escherichia coli replication fork: effect of dUTP.

Review 4. Recalibrated linkage map of Escherichia coli K-12.

5. Repair of cross-linked DNA and survival of Escherichia coli treated with psoralen and light: effects of mutations influencing genetic recombination and DNA metabolism.

6. Transient accumulation of Okazaki fragments as a result of uracil incorporation into nascent DNA.

7. Escherichia coli mutants deficient in exonuclease VII.

8. Sister chromatid exchange frequencies in Escherichia coli analyzed by recombination at the dif resolvase site.

9. Localization of the structural gene for threonine dehydrogenase in Escherichia coli.

10. Recombinant levels of Escherichia coli K-12 mutants deficient in various replication, recombination, or repair genes.