Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Slow joining of newly replicated DNA chains in DNA polymerase I-deficient Escherichia coli mutants.

Literature DB >> 4943548

Slow joining of newly replicated DNA chains in DNA polymerase I-deficient Escherichia coli mutants.

Abstract

In Escherichia coli mutants deficient in DNA polymerase I, newly replicated short DNA is joined at about 10% of the rate in the wild-type strains. It is postulated that DNA polymerase I normally functions in filling gaps between the nascent short segments synthesized by the replication complex. Possible implications of the finding are discussed in relation to other abnormal properties of these mutants.

Entities: Gene Species

Mesh：

Substances：

Year: 1971 PMID： 4943548 PMCID： PMC389568 DOI： 10.1073/pnas.68.12.2954

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

32 in total

1. Active center of DNA polymerase.

Authors: A Kornberg
Journal: Science Date: 1969-03-28 Impact factor: 47.728

2. Isolation of an E. coli strain with a mutation affecting DNA polymerase.

Authors: P De Lucia; J Cairns
Journal: Nature Date: 1969-12-20 Impact factor: 49.962

3. Genetic analysis of an E. coli strain with a mutation affecting DNA polymerase.

Authors: J Gross; M Gross
Journal: Nature Date: 1969-12-20 Impact factor: 49.962

4. Repair deficiency in a bacterial mutant defective in DNA polymerase.

Authors: L Kanner; P Hanawalt
Journal: Biochem Biophys Res Commun Date: 1970-04-08 Impact factor: 3.575

5. Enzymic synthesis of DNA. 33. Hydrolysis of a 5'-triphosphate-terminated polynucleotide in the active center of DNA polymerase.

Authors: N R Cozzarelli; R B Kelly; A Kornberg
Journal: J Mol Biol Date: 1969-11-14 Impact factor: 5.469

6. Mutagenesis of the replication point by nitrosoguanidine: map and pattern of replication of the Escherichia coli chromosome.

Authors: E Cerdá-Olmedo; P C Hanawalt; N Guerola
Journal: J Mol Biol Date: 1968-05-14 Impact factor: 5.469

7. Mechanism of DNA chain growth. I. Possible discontinuity and unusual secondary structure of newly synthesized chains.

Authors: R Okazaki; T Okazaki; K Sakabe; K Sugimoto; A Sugino
Journal: Proc Natl Acad Sci U S A Date: 1968-02 Impact factor: 11.205

8. Studies of DNA replication in vivo, II. Evidence for the second intermediate.

Authors: M Oishi
Journal: Proc Natl Acad Sci U S A Date: 1968-06 Impact factor: 11.205

9. Replication of phage lambda DNA.

Authors: J Tomizawa; T Ogawa
Journal: Cold Spring Harb Symp Quant Biol Date: 1968

10. Mechanism of DNA chain growth. 3. Equal annealing of T4 nascent short DNA chains with the separated complementary strands of the phage DNA.

Authors: K Sugimoto; T Okazaki; Y Imae; R Okazaki
Journal: Proc Natl Acad Sci U S A Date: 1969-08 Impact factor: 11.205

73 in total

Review 1. Colicinogeny and related phenomena.

Authors: K G Hardy
Journal: Bacteriol Rev Date: 1975-12

2. Increased spontaneous reversion of certain frameshift mutations in DNA polymerase I deficient strains of Escherichia coli.

Authors: K K Vaccaro; E C Siegel
Journal: Mol Gen Genet Date: 1975-12-01

Slow joining of newly replicated DNA chains in DNA polymerase I-deficient Escherichia coli mutants.

1. Active center of DNA polymerase.

2. Isolation of an E. coli strain with a mutation affecting DNA polymerase.

3. Genetic analysis of an E. coli strain with a mutation affecting DNA polymerase.

4. Repair deficiency in a bacterial mutant defective in DNA polymerase.

5. Enzymic synthesis of DNA. 33. Hydrolysis of a 5'-triphosphate-terminated polynucleotide in the active center of DNA polymerase.

6. Mutagenesis of the replication point by nitrosoguanidine: map and pattern of replication of the Escherichia coli chromosome.

7. Mechanism of DNA chain growth. I. Possible discontinuity and unusual secondary structure of newly synthesized chains.

8. Studies of DNA replication in vivo, II. Evidence for the second intermediate.

9. Replication of phage lambda DNA.

10. Mechanism of DNA chain growth. 3. Equal annealing of T4 nascent short DNA chains with the separated complementary strands of the phage DNA.

Review 1. Colicinogeny and related phenomena.

2. Increased spontaneous reversion of certain frameshift mutations in DNA polymerase I deficient strains of Escherichia coli.

3. Genetic and kinetic evidence for different types of postreplication repair in Escherichia coli B.

4. Role of the Escherichia coli nucleotide excision repair proteins in DNA replication.

Review 5. DNA replication fidelity in Escherichia coli: a multi-DNA polymerase affair.

6. The Escherichia coli dnaN159 mutant displays altered DNA polymerase usage and chronic SOS induction.

7. DNA polymerase I is not required for replication of linear chromosomes in streptomyces.

8. Transient accumulation of Okazaki fragments as a result of uracil incorporation into nascent DNA.

9. Sister chromatid exchange frequencies in Escherichia coli analyzed by recombination at the dif resolvase site.

10. DNA polymerase beta can substitute for DNA polymerase I in the initiation of plasmid DNA replication.